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马双刚

时间:2020/7/6 来源: 阅读:11007次


马双刚

 

马双刚,安徽桐城人,博士,副研究员,硕士研究生导师。

 

联系方式:

Tel: 010-63165324; E-mail:  mashuanggang@imm.ac.cn 

 

1999年本科毕业于沈阳药科大学中药制药专业,20047月获沈阳药科大学药物化学硕士学位,20087月获中国医学科学院&北京协和医学院药物化学博士学位,20088月至今在药物研究所天然药物化学研究室工作。研究方向为天然药物活性物质研究。

先后承担教育部新教师基金课题、医科院药物所基本科研基金科研重点与团队建设专项,国家自然基金面上项目、国家重点研发课题;参与国家自然科学基金面上项目及重点项目、十一五十二五十三五国家重大新药创制科技重大专项,中国医学科学院协同创新团队等科研项目。

近年来对少药八角等7种八角属植物开展了系统的化学成分和生物活性研究,发现新骨架化合物9个,发现抗病毒、抗炎、抗氧化、肿瘤细胞毒、神经细胞保护等活性化合物40余个。其中具有抗病毒活性的含有多个手性中心的螺环新骨架化合物spirooliganones A-B (Hot off the press)及其生源途径假说引起合成化学家的兴趣,先后被仿生全合成。研究结果在国际本领域重要期刊上发表SCI论文60余篇;获得中国授权专利14项,其中2项专利获得美国、欧盟、日本等国授权; 获得国家、省部级奖励5项,其中国家科技进步二等奖1 (2014-J-234-2-01-R09)、北京市科技进步奖一等奖1项(2013-1-001-09)、教育部自然科学一等奖1项(2010-38)。参编专著3部。

 

代表性论文:

1.     Yang-Lan Liu#, Wen-Rui Li#, Xiao-Jing Wang, Ru-Bing Wang, Mi Li, Jian-Pei Zhang, Jing-Yao Yong, Xiu-Qi Bao, Dan Zhang, Shuang-Gang Ma*. Highly oxidized sesquiterpenes from the fruits of Illicium lanceolatum. Phytochemistry 2020, 172, 112281.

2.     Yang-Lan Liu#, Xiao-Jing Wang#, Ru-Bing Wang, Mi Li, Wen-Rui Li, Jian-Pei Zhang, Xiu-Qi Bao, Dan Zhang, Shuang-Gang Ma*. New hexalactone derivatives and a pair of new oxaspiro-carbon epimeric glycosides from the fruits of Illicium lanceolatum. Bioorg. Chem. 2019, 91, 103113.

3.     Shuang-Gang Ma#, Ru-Bing Wang#, Wen-Rui Li, Yun-Bao Liu, Jing Qu, Yong Li, Xiao-Jing Wang, Song Xu, Shi-Shan Yu*. New C-2 diastereomers of avanone glycosides conjugated with 3-hydroxy3-methylglutaric acid from the pericarp of Citrus grandis (L.) Osbeck. Bioorg. Chem. 2018, 50, 519-524.

4.     Shuang-Gang Ma, Shao-Peng Yuan, Yun-Bao Liu, Jing Qu, Yong Li, Xiao-Jing Wang, Ru-Bing Wang, Song Xu, Qi Hou, Shi-Shan Yu*. 3-Hydroxy-3-methylglutaryl flavone glycosides from the leaves of Turpinia arguta. Fitoterapia 2018, 124, 80-85.

5.     Shuang-Gang Ma#, Mi Li#, Min-Bao Lin, Li Li, Yun-Bao Liu, Jing Qu*, Yong Li, Xiao-Jing Wang, Ru-Bing Wang, Song Xu, Qi Hou, and Shi-Shan Yu*. Illisimonin A, a caged sesquiterpenoid with a new tricyclo[5.2.1.01,6]decane skeleton from the fruits of Illicium simonsii. Org. Lett. 2017, 19, 6160−6163.

 

6.     Feng-Min Xi, Yun-Bao Liu, Jing Qu, Yong Li, Zhong-Hai Tang, Li Li, Yu-Huan Li, Xiao-Guang Chen, Shuang-Gang Ma*, and Shi-Shan Yu*. Bioactive sesquiterpenoids from the roots of Artabotrys hexapetalus. Tetrahedron 2017, 73, 571-582.

7.     Zhong-Hai Tang#, Yun-Bao Liu#, Shuang-Gang Ma#, Li Li, Yong Li, Jian-Dong Jiang, Jing Qu*, and Shi-Shan Yu*. Antiviral spirotriscoumarins A and B: two pairs of oligomeric coumarin enantiomers with a spirodienone−sesquiterpene skeleton from Toddalia asiatica. Org. Lett. 2016, 18, 5146-5149.

8.     Shuang-Gang Ma, Ya Gao, Hui-Qiang Wang, Yun-Bao Liu, Jing Qu, Yong Li, Li Li, Song Xu, Hai-Ning Lv, Yu-Huan Li, and Shi-Shan Yu*. Antiviral mono- and bis-prenylated C6-C3 derivatives from the roots of Illicium oligandrum. Tetrahedron 2016, 3003-3013.

9.     Feng-Min Xi, Shuang-Gang Ma, Yun-Bao Liu, Li Li, and Shi-Shan Yu*. Artaboterpenoids A and B, bisabolene-derived sesquiterpenoids from Artabotrys hexapetalus. Org. Lett. 2016, 18 (14), 3374–3377.

10.  Nan Zhao, Xiao-Dong Ren, Jin-Hong Ren, Hai-Ning Lü, Shuang-Gang Ma, Rong-Mei Gao, Yu-Huan Li, Song Xu, Li Li, and Shi-Shan Yu*. Total syntheses of (−)-spirooliganones A and B and their diastereoisomers: absolute stereochemistry and inhibitory activity against coxsackie virus B3. Org. Lett. 2015, 17 (12), 3118–3121.

11.  Xiao-Dong Ren, Nan Zhao, Song Xu, Hai-Ning Lü, Shuang-Gang Ma, Yun-Bao Liu, Yong Li, Jing Qu, Shi-Shan Yu. Total synthesis of illicidione A and illihendione A. Tetrahedron 2015, 71 (29), 4821-4829.

12.  Hai-Ning Lv, Song Xu, Shuang-Gang Ma, Yun-Bao Liu, Yong Li, Jing Qu, Shi-Shan Yu*. A novel asymmetric synthesis of (+)-deoxytylophorinine. Synthesis 2015, 47, 1399-1404.

13.  Hong-Shun Gu, Shuang-Gang Ma*, Jing Qu, Yun-Bao Liu, and Shi-Shan Yu*. Diketopiperazines and sesquilignans from the branches and leaves of Claoxylon polot. Planta Med. 2015, 81, 748-753.

14.  Hai-Ning Lv, Shuang-Gang Ma*, Yun-Bao Liu, Jing Qu, Yong Li, Song Xu, Hua Zhu*, Shi-Shan Yu*. Sesquiterpenes from the roots of Illicium oligandrum. J. Asian Nat. Prod. Res. 2015, 17(5): 430-438.

15.  Hong-Shun Gu, Shuang-Gang Ma, Yu-Huan Li, Ya-Dan Wang, Yun-Bao Liu, Li Li, Yong Li, Jing Qu*, Hai-Ning Lv, Xiao-Guang Chen, Jian-Dong Jiang, and Shi-Shan Yu*. Claoxylones A–I, prenylbisabolane diterpenoids with anti-coxsackie B virus activity from the branches and leaves of Claoxylon polot. Tetrahedron 2014, 70, 7476-7483.

16.  Shuang-Gang Ma, Rong-Mei Gao, Yu-Huan Li, Jian-Dong Jiang, Ning-Bo Gong, Li Li, Yang Lü, Wen-Zhao Tang, Yun-Bao Liu, Jing Qu, Hai-Ning Lü, Yong Li, and Shi-Shan Yu*. Antiviral spirooliganones A and B with unprecedented skeletons from the roots of Illicium oligandrum. Org. Lett. 2013, 15(17), 4450-4453.

17.  Peng-Yu Zhuang#, Shuang-Gang Ma#, Gui-Jie Zhang, Xiao-Jing Wang, Yan Zhang, Shi-Shan Yu*, Yun-Bao Liu, Jing Qu, Yong Li, and Qi Hou. Novel prenylated C6−C3 compounds from the roots of Illicium henryi. Phytochemistry Lett. 2013, 6(3), 444-448.

18.  Hui Chen#, Shuang-Gang Ma#, Zhen-Feng Fang, Jian Bai, Shi-Shan Yu*, Xiao-Guang Chen, Qi Hou, Shao-Peng Yuan, and Xia Chen. Tirucallane triterpenoids from the stems of Brucea mollis. Chem. & Biodiv. 2013, 10, 695-701.

19.  Hai-Ning Lv, Jin-Hong Ren, Shuang-Gang Ma, Song Xu, Jing Qu, Zhen-Jia Liu, Qin Zhou, Xiao-Guang Chen, Shi-Shan Yu*. Synthesis, biological evaluation and mechanism studies of deoxytylophorinine and its derivatives as potential anticancer agents. PLoS ONE 2012, 7, e30342.

20.  Shuang-Gang Ma, Wen-Zhao Tang, Yu-Xi Liu, You-Cai Hu, Shi-Shan Yu*, Yi Zhang, Xiao-Guang Chen, Jing Qu, Jin-Hong Ren, Yun-Bao Liu, Song Xu, Jing Liu, Yuan-Yan Liu, Yong Li, Hai-Ning Lü, and Xian-Fu Wu. Prenylated C6-C3 compounds with molecular diversity from the roots of Illicium oligandrum. Phytochemistry 2011, 72(1), 115-125.

21.  Shuang-Gang Ma#, Wen-Zhao Tang#, Shi-Shan Yu*, Xiao-Guang Chen, Yang Liu, Wen-Jie Wang, Jing Qu, Song Xu, Jin-Hong Ren, Yong Li, and Hai-Ning Lü. Four new phenolic diglycosides from the roots of Illicium oligandrum. Carbohydr. Res. 2011, 346(9), 1165-1168.

22.  Wen-Zhao Tang#, Shuang-Gang Ma#, Jing Qu, Shi-Shan Yu*, Yun-Bao Liu, Dong-Min Su, and Jing Liu. Dimeric prenylated C6-C3 compounds from the stem bark of Illicium oligandrum. J. Nat. Prod. 2011, 74(5), 1268-1271.

23.   Rui Liu, Shuang-Gang Ma, Yu-Xi Liu, Shi-Shan Yu*, Xiao-Guang Chen, and Jian-Jun Zhang. Albizosides D and E, two new cytotoxic triterpene saponins from Albizia chinensisCarbohydr. Res. 2010, 345(13), 1877-1881.

24.  Wen-Zhao Tang, Shuang-Gang Ma, Shi-Shan Yu*, Jing Qu, Yun-Bao Liu, and Jing Liu. Rearranged prenylated C6-C3 compounds and a highly oxygenated seco-prezizaane-type sesquiterpene from the stem bark of Illicium oligandrumJ. Nat. Prod. 2009, 72(6), 1017-1021.

25.  Rui Liu, Shuang-Gang Ma, Shi-Shan Yu*, Yue-Hu Pei, Sen Zhang, Xiao-Guang Chen, and Jian-Jun Zhang. Cytotoxic oleanane triterpene saponins from Albizia chinensisJ. Nat. Prod. 2009, 72(4), 632-639.

26.   Shuang-Gang Ma, You-Cai Hu, Shi-Shan Yu*, Yi Zhang, Xiao-Guang Chen, Jing Liu, and Yu-Xi Liu. Cytotoxic triterpenoid saponins acylated with monoterpenic acid from Pithecellobium lucidumJ. Nat. Prod. 2008, 71(1), 41-46.

27.  刘阳澜,李文睿,张建培,雍锦瑶,张丹,马双刚*. 披针叶茴香果实中seco-prezizaane 型倍半萜及其神经保护活性研究.中国中药杂志 201944(19),4207-4211.

28.  马双刚,袁绍鹏,侯琦,李勇,陈霞,庾石山*.山香圆叶中黄酮苷类成分及其抗炎活性研究.中国中药杂志 2013,38(11),1747-1750.

29.  马双刚,吕海宁,丁广治,庾石山*,陈晓光,亮叶围涎树根的化学成分及其肿瘤细胞毒活性研究.中国中药杂志 2011,36(13),1769-1771.

    *corresponding author; #equal contribution

 

参编专著:

1.      《三萜化学》,庾石山 主编,化学工业出版社,200810月。

2.      《中草药现代研究(第五卷)》,协和医科大学出版社,201011月。

3.      《高速发展的中国化学:1982—2012》,科学出版社,20124月。

 

 

 

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