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时间:2020/7/17 来源: 阅读:25307次






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1989.9-1994.7 河北医学院临床医学专业,获学士学位

1996.9-1999.7    华西医科大学药理学专业,获硕士学位

1996.9-1999.8  协和医科大学药物研究所药理学专业,获博士学位




1999.9-2001.7  中国医学科学院药物研究所,研究实习员

2004.9-2008.4  哈佛大学医学院,Brigham and Women’s Hospital神经疾病中心,博士后、讲师

2008.4-2009.10  中国医学科学院药物研究所,助理研究员

2009.10-2015.9  中国医学科学院药物研究所,副研究员

2015.10-        中国医学科学院药物研究所,研究员



1. 阿尔茨海默病、肌萎缩性侧索硬化症的发病机制研究;

2. 脑血管、神经精神系统疾病(主要是缺血性脑卒中、阿尔茨海默病、肌萎缩性侧索硬化症、多发性硬化症、脑外伤和焦虑症)药物筛选及药效学评价标准化技术体系的建设及创新药物研发。




1.      Zhang Y, Shi Z, Zhou Y, Xiao Q, Wang H, Peng Y*. Emerging substrate proteins of Kelch-like ECH associated protein 1 (Keap1) and potential challenges for the development of small-molecule inhibitors of the Keap1-nuclear factor erythroid 2-related factor 2 (Nrf2) protein-protein interaction. J Med Chem. 2020 Apr 1.

2.      Tang JS, Kang YY, Huang LJ, Wu L, Peng Y*. TIMP1 preserves the blood–brain barrier through interacting with CD63/integrin β1 complex and regulating downstream FAK/RhoA signaling. Acta Pharmaceutics Sinica B. 2020;10(6):987-1003.

3.      Huang L, Zhang Y, Peng Y, Zhao Z, Zhou Y, Wang X*, Peng Y*. Protective effect of potassium 2-(l-hydroxypentyl)-benzoate on hippocampal neurons, synapses and dystrophic axons in APP/PS1 mice. Psychopharmacology (Berl). 2019;236(9):2761-2771.

4.      Wang S, Huang L, Zhang Y, Peng YC, Wang XL*, Peng Y*. Protective effects of L-3-n-butylphthalide against H2O2-induced injury in Neural Stem Cells by activation of PI3K/Akt and Mash1 pathway. Neuroscience 2018;393:164-174.

5.      Peng YC, Wang S, Zhang Y, Huang L, Wang XL*, Peng Y*. Hsp90β inhibitors prevent GLT-1 degradation but have no beneficial efficacy on absence epilepsy. J Asian Nat Prod Res. 2018;17:1-11.

6.      Huang L, Wang S, Ma F, Zhang Y, Peng Y, Xing C, Feng Y, Wang X*, Peng Y*. From stroke to neurodegenerative diseases: The multi-target neuroprotective effects of 3-n-butylphthalide and its derivatives. Pharmacol Res. 2018;135:201-211.

7.      Wang S, Ma F, Huang L, Zhang Y, Peng YC, Xing CH, Feng YP, Wang XL*, Peng Y*. Dl-3-n-Butylphthalide: A Promising Therapeutic Agent for Ischemic Stroke. CNS & Neurological Disorders-Drug Targets. 2018;17(5):338-347.

8.      Lei H#, Zhang Y#, Huang L, Xu S, Li J, Yang L, Wang L, Xing C, Wang X*, Peng Y*. L-3-n-Butylphthalide Regulates Proliferation, Migration, and Differentiation of Neural Stem Cell In Vitro and Promotes Neurogenesis in APP/PS1 Mouse Model by Regulating BDNF/TrkB/CREB/Akt Pathway. Neurotox Res. 2018;34(3):477-488.

9.      Qiu H, Wu H, Ma J, Cao H, Huang L, Qiu W, Peng Y*, Ding C*. DL-3-n-Butylphthalide reduces atrial fibrillation susceptibility by inhibiting atrial structural remodeling in rats with heart failure. Naunyn Schmiedebergs Arch Pharmacol. 2018;391(3):323-334.

10.   Zhao CY#, Hou WZ#, Lei H, Huang LJ, Wang S, Cui DD, Xiang CH, Wang XL*, Peng Y*. Potassium 2-(l-hydroxypentyl)-benzoate attenuates neuroinflammatory responses and upregulates heme oxygenase-1 in systemic lipopolysaccharide-induced inflammation in mice. Acta Pharmaceutica Sinica B, 2017;7(4):470-478.

11.   Li L, Xu SF, Liu LF, Feng RT, Gong YX, Zhao XY*, Li J, Cai J, Feng N, Wang L, Wang XL*, Peng Y*. Multifunctional Compound AD-35 Improves Cognitive Impairment and Attenuates the Production of TNF-α and IL-1β in an Aβ25-35-induced Rat Model of Alzheimer’s Disease. J Alzheimers Dis. 2017;56(4):1403-1417.

12.   Wang R, Chen R, Li J, Liu X, Xie K, Chen D, Peng Y*, Dai J*. Regiospecific Prenylation of Hydroxyxanthones by a Plant Flavonoid Prenyltransferase. J Nat Prod. 2016;79(8):2143-2147.

13.   Zhang Y, Huang LJ, Shi S, Xu SF, Wang XL*, Peng Y*. L-3-n-butylphthalide Rescues Hippocampal Synaptic Failure and Attenuates Neuropathology in Aged APP/PS1 Mouse Model of Alzheimer's Disease. CNS Neurosci Ther. 2016;22(12):979-987.

14.   Wang F, Ma J, Han F, Guo X, Meng L, Sun Y, Jin C, Duan H, Li H*, Peng Y*. DL-3-n-butylphthalide delays the onset and progression of diabetic cataract by inhibiting oxidative stress in rat diabetic model. Sci Rep. 2016;6:19396.

15.   Zhao CY Lei H, Zhang Y, Li L, Xu SF, Cai J, Wang XL*, Peng Y*. L-3-n-butylphthalide attenuates neuroinflammatory responses by downregulating JNK activation and up-regulates Heme oxygenase-1 in lipopolysaccharide-treated mice. J Asian Nat Prod Res. 2016; 18(3):289-302.

16.   Yang LC, Li J, Lei H, Liu DM, Zhang M, Rong XF, Wang L, Peng Y*, Wang XL*. L-3-n-butylphthalide Promotes Neurogenesis and Neuroplasticity After Focal Cerebral Ischemia in Rats. CNS Neurosci Ther. 2015;21(9):733-41.



1.    应用分子药理学》第二版,参与编写,中国协和医科大学出版社,2015年。

2.    《药理学研究的新技术与新方法》,参与编写,中国协和医科大学出版社,2014年。

3.    《现代药理实验方法》第二版,参与编写,中国协和医科大学出版社,2012年。

4.    《药理学研究的新思路与新靶点》,参与编写,中国协和医科大学出版社,2012年。