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陈艳华

时间:2016/8/30 来源: 阅读:9771次


陈艳华

 

陈艳华  博士,副研究员,硕士生导师

 

教育背景:

1999/09-2003/07   吉林大学,药学专业,学士

2003/09-2006/07   吉林大学,生化与分子生物学专业,硕士

2006/09-2009/07   中国医学科学院药物研究所,药物分析专业,博士

 

工作经历:

2009/08-至今,中国医学科学院&北京协和医学院药物研究所,国家药物及代谢产物分析研究中心,助理研究员、副研究员。

 

联系方式:

联系电话:010-63165218

联系邮箱:chenyanhua@imm.ac.cn

 

专业研究方向领域:

1、代谢组学分析新方法及其在重大疾病中的应用研究;

2、定量代谢组学分析新方法研究;

3、药物代谢组学和药物体内代谢过程研究。

主要从事基于质谱技术的快速分析新方法研究。采用多重离子化、多功能整合的MS/MSLC-MS/MS等质谱联用技术及手段,开展恶性肿瘤等重大疾病的代谢组学高通量分析方法研究,寻找并发现与疾病诊断及治疗密切相关的小分子生物标志物。此外,还开展基于动物模型的药物代谢组学及药物体内代谢过程研究。近年来,先后承担及参与国家级和科技部科研项目近10项。目前,共发表SCI论文18篇,其中第一作者文章7篇,包括Analytical Chemistry, Molecular & Cellular Proteomics, AnalystJournal of Proteome Research等。曾获2014年中国分析测试协会科学技术奖(CAIA奖)一等奖(第二完成人),2013年获北京高等学校青年英才计划资助。

 

近年发表论文:

(1)   Yanhua Chen#, Jing Xu#, Ruiping Zhang, Zeper Abliz*. Methods used to increase the comprehensive coverage of urinary and plasma metabolomes by MS. Bioanalysis. 2016, 8(9): 981-997.

(2)   Yanhua Chen, Guoqing Shen, Ruiping Zhang, Jiuming He,  Yi Zhang, Jing Xu, Wei Yang, Xiaoguang Chen, Yongmei Song, Zeper Abliz*. Combination of Injection Volume Calibration by Creatinine and MS Signals’Normalization to Overcome Urine Variability in LC-MS-Based Metabolomics Studies. Anal. Chem, 2013, 85: 7659−7665.

(3)   Yanhua Chen, Jing Xu, Ruiping Zhang, GuoqingShen, Yongmei Song, Jianghao Sun, Jiuming He, Qimin Zhan, Zeper Abliz*. Assessment of data pre-processing methods for LC-MS/MS-based metabolomics of uterine cervix cancer. Analyst, 2013, 138: 2669-2677.

(4)   Jing  Xu#, Yanhua  Chen#,  Ruiping  Zhang,  Yongmei  Song, Jianzhong Cao, Nan Bi, Jingbo Wang, Jiuming He, Jinfa Bai, Lijia Dong, Luhua Wang,  Qimin  Zhan,  Zeper  Abliz*. Global and Targeted Metabolomics of Esophageal Squamous Cell Carcinoma Discovers Potential Diagnostic and Therapeutic Biomarkers. Mol Cell Proteomics, 2013, 12: 1306-1318.

(5)   陈艳华, 张瑞萍, 宋咏梅, 董立佳, 詹启敏, 再帕尔阿不力孜*. 基于快速高分辨液相色谱串联质谱技术的代谢组学尿液分析方法的建立, 分析化学, 2011, 39(2): 173-177.

(6)   Yanhua Chen, Ruiping Zhang, Yongmei Song, Jiuming He, Jianghao Sun, Jinfa Bai, Zhuoling An, Lijia Dong , Qimin Zhan, Zeper Abliz*. RRLC-MS/MS-based metabonomics combined with in-depth analysis of metabolic correlation network: finding potential biomarkers for breast cancer. Analyst, 2009, 134: 2003–2011

(7)   Wei Yang, Yanhua Chen, Cong Xi, Ruiping Zhang, Yongmei Song, Qimin Zhan, Xiaofeng Bi, Zeper Abliz*. Liquid chromatography–tandem mass spectrometry-based plasma metabonomics delineate the effect of metabolites’ stability on reliability of potential biomarkers. Analytical Chemistry. 2013, 85(5): 2606-2610.

(8)   Guoqing Shen, Yanhua Chen, Jianghao Sun, Ruiping Zhang, Yi Zhang, Jiuming He, Yaping Tian, Yongmei Song, Xiaoguang Chen, Zeper Abliz*. Time-Course changes in potential biomarkers detected using a metabonomic approach in Walker 256 tumor-bearing rats. Journal of Proteome Research. 2011, 10(4): 1953-1961.

(9)   Zhuoling An, Yanhua Chen, Ruiping Zhang, Yongmei Song, Jianghao Sun, Jiuming He, Jinfa Bai, Lijia Dong, Qimin Zhan and Zeper Abliz*. Integrated Ionization Approach for RRLC-MS/MS-based Metabonomics: Finding Potential Biomarkers for Lung Cancer. J Proteome Res., 2010, 9(8): 4071-4081.

(10) Huiqing Wang, Jing Xu, Yanhua Chen, Ruiping Zhang, Jiuming He, Zhonghua Wang, Qingce Zang, Jinfeng Wei, Xiaowei Song, and Zeper Abliz*. Optimization and evaluation strategy of esophageal tissue preparation protocols for metabolomics by LC−MS. Analytical Chemistry. 2016, 88(7) : 3459-3464.

(11) Jiang Huang, Jianghao Sun, Yanhua Chen, Yongmei Song, Lijia Dong, Qinmin Zhan, Ruiping Zhang*, Zeper Abliz*. Analysis of multiplex endogenous estrogen metabolites in human urine using ultra-fast liquid chromatography–tandem mass spectrometry: A case study for breast cancer. Analytica Chimica Acta. 2012, 711: 60-68.

(12) Jing Xu, Yaping Tian, Yanhua Chen, Ruiping Zhang, Fen Yang, Yongmei Song, Zeper Abliz*. Plasma preparation method for metabolomic analysis based on rapid resolution liquid chromatography-mass spectrometry. Chinese Journal of Analytical Chemistry. 2011, 39(12): 1793-1797.

(13) He Tian, Jinfa Bai, Zhuoling An, Yanhua Chen, Ruiping Zhang, Jiuming He, Xiaofeng Bi, Yongmei Song, Zeper Abliz*. Plasma metabolome analysis by integrated ionization rapid-resolution liquid chromatography/tandem mass spectrometry. Rapid Communications in Mass Spectrometry. 2013, 27(18): 2071-2080.

(14) Yan Gao, Ruiping Zhang, Jinfa Bai, Xuejun Xia, Yanhua Chen, Zhigang Luo, Jing Xu, Yang Gao, Yuling Liu, Jiuming He*, Zeper Abliz*. Targeted Data-Independent Acquisition and Mining Strategy for Trace Drug Metabolite Identification Using Liquid Chromatography Coupled with Tandem Mass Spectrometry. Analytical Chemistry. 2015, 87(15): 7535-7539.

(15) Yaping Tian, Jiuming He, Ruiping Zhang*, Haining Lv, Shuanggang Ma, Yanhua Chen, Shishan Yu, Xiaoguang Chen, Yan Wu, Wenyi He, Zeper Abliz*. Integrated rapid resolution liquid chromatography-tandem mass spectrometric approach for screening and identification of metabolites of the potential anticancer agent 3, 6, 7-trimethoxyphenanthroindolizidine in rat urine. Analytica Chimica Acta. 2012, 731: 60-67.

(16) Zhonghua Wang, Yajie Zheng, Baoxin Zhao, Yanping Zhang, Zhe Liu, Jing Xu, Yanhua Chen, Zhao Yang, Fenfen Wang, Huiqing Wang, Jiuming He, Ruiping Zhang*, Zeper Abliz*. Human metabolic responses to chronic environmental polycyclic aromatic hydrocarbon exposure by a metabolomic approach. Journal of Proteome Research. 2015, 14(6): 2583-2593.

 

 

 

 

 

 

 

 

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