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吉腾飞

时间:2020/7/20 来源: 阅读:26075次


吉腾飞

 

吉腾飞 博士,研究员,博士研究生导师。

联系方式

Tel010-63165226E-mail: jitf@imm.ac.cn

 

教育背景

1999.09-2003.01中国医学科学院&北京协和医学院药物研究所,理学博士

1996.09-1999.07中国科学院新疆化学研究所,理学硕士

1992.09-1996.07 新疆师范大学化学系,理学学士

 

工作经历

2015.10  至今       中国医学科学院&北京协和医学院,药物研究所,研究员

2009.10-2015.09   中国医学科学院&北京协和医学院,药物研究所,副研究员

2012.09-2013.08   新疆维吾尔自治区药物研究所,副主任,副研究员

2003.07-2009.09 中国医学科学院&北京协和医学院,药物研究所,助理研究员

 

专业研究领域

1.      常用传统中药的药效物质基础研究

2.      基于活性天然产物的新药研究开发

研究方向是基于中药临床用药基础,结合传统功效,与药理学科合作,以药理活性为导向,采用分离纯化新技术,明确其药效物质基础;同时以药效物质为先导结构和分子模板,针对其骨架结构特点,采取多样化的结构优化策略;研究药效物质药理活性、作用靶标和成药性等规律,进而开发具有抗炎症相关疾病、代谢性疾病和抗肿瘤的创新药物。主持和参加国家自然科学基金、中央科研公益基金重点与团队课题、国家创新药物研究开发综合性大平台、新疆科技支撑计划项目、“重大新药创制”科技重大专项和中药新药发现与评价技术平台和中药标准物质研制和开发的技术平台建设等项目。目前已发表论文60余篇,其中SCI收录40余篇,申请专利20余项。曾获得宁夏科学技术进步奖二等奖一项;江西省科学技术进步奖三等奖一项;中国药学会科学技术奖二等奖一项。

发表论文

1.      Jin-ying Tian, Rong-ya Tao, Xiao-lin Zhang, Qian Liu, Yi-bo He, Ya-lun Su, Teng-fei Ji*, Fei Ye*, Effect of Hypericum perforatum L. extract on insulin resistance and lipid metabolic disorder in high-fat-diet induced obese mice, Phytotherapy Research, 2015, 29:86-92.

2.      Wan Gao, Wei-Zhen Hou, Jun Zhao, Fang Xu, Li Li, Fang Xu, Hua Sun, Jian-Guo Xing, Ying Peng, Xiao-Liang Wang, Teng-Fei Ji* and Zheng-Yi Gu*, Polycyclic Polyprenylated Acylphloroglucinol Congeners from Hypericum scabrum, J. Nat. Prod., 2016,79 (6):1538–1547.

3.      Wan Gao, Jia-Wen Hu, Fang Xu, Chan-Jing Wei, Meng-Jiao Shi, Jun Zhao, Jia-Jia Wang, Bo Zhen, Teng-Fei Ji*,Jian-Guo Xing, Zheng-Yi Gu* and Fang Xu*, Polyisoprenylated benzoylphloroglucinol derivatives from Hypericum scabrum, Fitoterapia, 2016,115: 128-134.

4.      Wan Gao, Jia-Wen Hu, Wei-Zhen Hou, Fang Xu, Jun Zhao, Fang Xu, Hua Sun, Jian-Guo Xing,Ying Peng, Xiao-Liang Wang, Teng-Fei Ji*, Li Li*, Zheng-Yi Gu*, Four new prenylated phloroglucinol derivatives from Hypericum scabrum, Tetrahedron Lett., 2016, 57, 2244-2248.

5.      Jiawen Hu, Wan Gao, Fang Xu, Canjing Wei, Mengjiao Shi, Hua Sun, Bo Zhen, Jiajia Wang, Tengfei Ji*, Jiandong Jiang*, Polycyclic polyprenylated acylphloroglucinol derivatives from Hypericum scabrum, Bioorg. Med. Chem. Lett., 2017,27(21):4932-4936.

6.      Di-Zao Li, Qiang-Zhe Zhanga, Cun-Ying Wang, Yan-Ling Zhang, Xing-Yu Li, Ji-Tao Huang, Hong-Yan Liu, Zhao-Di Fu, Hua-Xian Song, Jin-Ping Lin, Teng-Fei Ji*, Xian-Dao Pan*, Synthesis and antitumor activity of novel substituted uracil-1(N)-acetic acid ester derivatives of 20(S)-camptothecins, Eur J Med Chem, 2017, 125: 1235-1246.

7.      Jihong Nie*, Fang Wang, Tengfei Ji*, Jun Zhao, Feicui Zhao, Assessment of in vitro cardio- toxicity of extract fractions and diterpene alkaloids from Aconitum leucostomum Worosch: A short communication, Journal of Pharmaceutical and Biomedical Analysis,2017, 137:84-89.

8.      Jun Zhao, Shilei Zhang, Shuping You, Tao Liu*, Fang Xu, Tengfei Ji*, Gu Zhengyi*Hepatoprotective Effects of Nicotiflorin from Nymphaea candida against Concanavalin A - Induced and D-Galactosamine - Induced Liver Injury in Mice, Int. J. Mol. Sci., 2017, 18(3), 587; doi:10.3390/ijms18030587.

9.      Wan Li, Jinyi Liu, Weiqi Fu, Xiangjin Zheng, Liwen Ren, Shiwei Liu, Jinhua Wang*, Tengfei Ji* and Guanhua Du*, 3-O-acetyl-11-keto-β-boswellic acid exerts anti-tumor effects in glioblastoma by arresting cell cycle at G2/M phase, J Exp Clin Canc Res,2018, 37:132.

10.   Can-Jing Wei, Fang Xu, Meng-Jiao Shi, Jia-Wen Hu, Jia-Jia Wang, Bo Zhen, Xue Wang, Teng-Fei Ji*, Jin-Hua Wang* & Guan-Hua Du*, Synthesis and antitumor activities of sinomenine derivatives on rings A and C, J Asian Nat Prod Res,2018, 20 (3): 277-291.

11.   Jia-Wen Hu, Meng-Jiao Shi, Jia-Jia Wang, Li Li, Jian-Dong Jiang*, Teng-Fei Ji*Methylated Polycyclic Polyprenylated Acylphloroglucinol Derivatives from Hypericum ascyron, J. Nat. Prod., 2018, 81, 2348−235.

12.   Jiajia Wang, Bo Zhen, Jiawen Hu, Mengjiao Shi, Canjing Wei, Xue Wang, Hua Sun, Tengfei Ji*, Boscartins L–O: Cembrane-type diterpenoids from the gum resin of Boswellia sacra Flueck., Phytochemistry, 2019,163:126–131.

13.   Bo Zhen, Jia-Wen Hu, Jia-Jia Wang, Meng-Jiao Shi, Li Li, Ren Ci, Jian-Dong Jiang*,Teng-Fei Ji*, Hyperascyrins LN, rare methylated polycyclic polyprenylated acylphloroglucinol derivatives from Hypericum ascyron, J Asian Nat Prod Res, 2019, 21( 5):409-418.

14.   Wan Li, Liwen Ren, Xiangjin Zheng, Jinyi Liu, Jinhua Wang*, Tengfei Ji*, Guanhua Du*3-O-acetyl-11-keto-β-boswellic acid ameliorated aberrant metabolic landscape and inhibited autophagy in glioblastoma, Acta Pharmaceutica Sinica B, 2020, 10(2):301-312.

15.   Jun Dang, Chengbiao Chen, Jianbin Ma, YangZom Dawa, Qi Wang, Yanduo Tao, Qilan Wang*, Tengfei Ji*Preparative isolation of highly polar free radical inhibitor from Floccularia luteovirens using hydrophilic interaction chromatography directed by on-line HPLC-DPPH assayJournal of Chromatography B, 2020,1142:122043.

16.   Xue Wang, Mengjiao Shi, Jiajia Wang, Xinyue Suo, Haoran Sun, Bo Zhen, Hua Sun, Jianguang Li*, Tengfei Ji*, Hyperacmosins E-G, three new homoadamantane-type polyprenylated acylphloroglucinols from Hypericum acmosepalum, Fitoterapia, 2020,142 :104535.

17.   Xue Wang, Jia-Jia Wang, Xin-Yue Suo, Hao-Ran Sun, Bo Zhen, Hua Sun, Jian-Guang Li*Teng-Fei Ji*, Hyperacmosins H-J, three new polycyclic polyprenylated acylphloroglucinol derivatives from Hypericum acmosepalum, J Asian Nat Prod Res, 2020, 22(6): 521-530.

18.   Jia-Jia Wang, Hao-Ran Sun, Xin-Yue Suo, Xue Wang, Hua Sun, Xiao-Liang Wang, Jian-Dong Jiang*, Teng-Fei Ji*Ten undescribed cembrane-type diterpenoids from the gum resin of Boswellia sacra and their biological activities, Phytochemistry, 2020, 177:112425.

 

专著

1.      参与编写《中国食用药用真菌化学》,上海科学技术文献出版社,2016年…

 

专利

1.      一种具有降血糖活性的中药提取物、制法、组合与用途(ZL 200610092038 1

2.      金丝桃属提取物、其制法及其药物组合物与治疗糖尿病的用途

ZL200710064489.9

 

 

 

 

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