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李莉

时间:2018/10/17 来源: 阅读:19996次


李莉

 

李莉 博士,研究员,博士生导师

 

教育背景

19939-19977月 北京师范大学化学系 化学专业 本科

19979-20026月 中国医学科学院放射医学研究所 影像医学与核医学专业 博士

 

联系方式

电话:010-63165247

E-mail: annaleelin@imm.ac.cn

 

工作经历

20027-20046月 中国医学科学院药物研究所 药学专业 博士后

20047月至今 中国医学科学院药物研究所副研究员,研究员

 

专业研究领域

1.      手性光谱学的基础与应用研究,包括天然产物和手性药物的立体结构表征、不对称反应的过程分析、手性传感体系的构建与应用、生物大分子的空间结构与相互作用研究;

2.      手性药物的研发,主要针对肿瘤和神经退行性疾病。

 

近年来主要论文

1.      Wen-Qiang Liu, Fang-Fang Lai, Jie Zhang, Li Sheng, Yan Li, Li Li*, Xiao-Guang Chen*. Chiral resolution, absolute configuration determination, and stereo-activity relationship study of the IDO1 inhibitor NLG919. Tetrahedron, 2018, 74 (24), 3045-3051.

2.      Guozhu Su, Shungang Jiao, Ruifei Zhang, Li Li*, Suyile Chen, Pengfei Tu, Xingyun Chai*. Alashinol H, an epoxylignan with an unusual six-membered cyclic hemiacetal from Syringa pinnatifolia. Tetrahedron Letters, 2018, 59, 1356-1359.

3.      Zhiguo Liu, Xilong Zheng, Yanan Wang, Mengyue Tang, Shilin Chen, Fangbo Zhang, Li Li,* Cun Zhang*, Yi Sun*. Lignans and isoflavonoids from the stems of Pisonia umbellifera. RSC Advances, 2018, 8, 16383-16391.

4.      Bo Li, Jie Zhang, Bei-Bei Yang, Li Li*, Xiao-Xiao Yang*. Ring-locking strategy facilitating determination of absolute optical purity of 2-amino-1-butanol by reverse-phase high-performance liquid chromatography. RSC Advances, 2017, 7, 45714-45720.

5.      Xiang Zhang, Ming-Chao Wang, Li Li*, Da-Li Yin*. A high-performance liquid chromatography-electronic circular dichroism online method for assessing the absolute enantiomeric excess and conversion ratio of asymmetric reactions. Scientific Reports, 2017, 7: 43278.

6.      Bo Li, Jie Zhang, Yongjuan Xu, Xiaoxiao Yang*, Li Li*. Improved synthesis of unnatural amino acids for peptide stapling. Tetrahedron Letters, 2017, 58(24): 2374–2377.

7.      Qian Li, An-Jun Deng, Li Li*, Lian-Qiu Wu, Ming Ji, Hai-Jing Zhang, Zhi-Hong Li, Lin Ma, Zhi-Hui Zhang, Xiao-Guang Chen, and Hai-Lin Qin*. Azacyclo-indoles and Phenolics from the Flowers of Juglans regia. Journal of Natural Products, 2017, 80, 2189-2198.

8.      An-Jun Deng, Hai-Jing Zhang, Qian Li, Zhi-Hong Li, Zhi-Hui Zhang, Lian-Qiu Wu, Li Li*, Hai-Lin Qin*. Six scalemic mixtures of 6-monosubstituted dihydrobenzophenanthridine alkaloids from Chelidonium majus and optically active structures of enantiomers. Phytochemistry, 2017, 14, 159-170.

9.      Junjie Han*, Congcong Liu*, Li Li*, Hui Zhou, Li Liu, Li Bao, Qian Chen, Fuhang Song, Lixin Zhang, Erwei Li, Ling Liu, Yunfei Pei, Cheng Jin, Yanfen Xue, Wenbing Yin, Yanhe Ma, Hongwei Liu. Decalin-Containing Tetramic acids and 4-hydroxy-2-pyridones with Antimicrobial and Cytotoxic Activity from the Fungus Coniochaeta cephalothecoides Collected in Tibetan Plateau (Medog). The Journal of Organic Chemistry, 2017, 82, 11474-11486.

10.   Wan Gao, Jia-Wen Hu, Wei-Zhen Hou, Fang Xu, Jun Zhao, Fang Xu, Hua Sun, Jian-Guo Xing, Ying Peng, Xiao-Liang Wang, Teng-Fei Ji*, Li Li*, Zheng-Yi Gu*. Four new prenylated phloroglucinol derivatives from Hypericum scabrum. Tetrahedron Letters, 2016, 57(21): 2244–2248.

11.   Xu Yin, Ruifeng Bai, Qiang Guo, Guozhu Su, Jing Wang, Xinyao Yang, Li Li*, Pengfei Tu, Xingyun Chai*. Hendersine A, a novel isoquinoline alkaloid from Corydalis hendersonii. Tetrahedron Letters, 2016, 57(43): 4858–4862.

12.   Jian-Bo Yang#, Li Li#, Zhong Dai, Yu Wu, Xing-Chao Geng, Bo Li, Shuang-Cheng Ma, Ai-Guo Wang, Ya-Lun Su. Polygonumnolides C1-C4; minor dianthrone glycosides from the roots of Polygonum multiflorum Thunb. Journal of Asian Natural Products Research, 2016, 18(9): 813-822.

13.   Ke Ma#, Li Li#, Li Bao, Luwei He, Chen Sun, Bing Zhou, Shuyi Si, Hongwei Liu. Six new 3,4-seco-27-norlanostane triterpenes from the medicinal mushroom Ganoderma boninense and their antiplasmodial activity and agonistic activity to LXRbb. Tetrahedron, 2015, 71(12): 1808-1814.

14.   Li Li, Lin Wang, Yi-Kang Si. Electronic circular dichroism behavior of chiral Phthiobuzone. Acta Pharmaceutica Sinica B, 2014, 4(2), 167-171.

15.   Li Li, Bei-Bei Yang, Yi-Kang Si. Chiroptical properties of artemisinin and artemether investigated using time-dependent density functional theory. Chinese Chemical Letters, 2014, 25, 1586-1590.

 

专利

1.      周柔丽,刘刚,李茂进,李莉,单毅,王琳,杨华。乙二醛基双缩氨基硫脲类化合物的新用途,公开号:CN101569619

2.      冯志强,陈晓光,李燕,尹桂林,金小峰,李莉。含噻唑环的丙炔酰胺类衍生物及其制法和药物组合物与用途。申请号:201410133649.0

3.      冯志强,陈晓光,李燕,王景静,金小峰,李莉。含噁唑环的丙炔酰胺类衍生物及其制法和药物组合物与用途。申请号:201410132933.6

4.      冯志强,王景静,李莉。偶氮苯衍生物及其制法和药物组合物与用途。申请号:201410542375.0

5.      冯志强,陈晓光,李燕,王景静,周婉琪,郑若男,李莉。苯并噁唑衍生物及其制法和药物组合物与用途。申请号:201611266272.1

6.      李莉,王琳,张丹,鲍秀琦,高琦,臧彩霞,郑远鹏。香豆素曼尼希碱及其在防治神经退行性疾病中的用途。申请号:201611177885.8

7.      李莉,刘文强,张洁,杨蓓蓓。1-环己基-2-(5H-咪唑[5,1-a]异吲哚)乙基-1-酮的拆分。申请号:201611213882.5

8.      李莉,张洁,李博,杨蓓蓓,熊斐,陶登,刘文强,卢家民。一种识别氨基酸及肽类化合物绝对构型和光学纯度的方法。申请号:201810235875.8

 

 

 

 

 

 

 

 

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