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秦海林

时间:2016/4/21 来源: 阅读:20834次


秦海林

 

 

 

1984年毕业于河南中医学院(现河南中医药大学),医学学士。1999年毕业于郑州大学化学系有机化学专业,有机化学博士。1984年-1999年在河南化学研究所从事天然药物化学及有机合成化学研究,任研究实习员、助理研究员。1999年-2001年在中国药科大学从事博士后研究,任助理研究员。20019月至今在中国医学科学院/北京协和医学院药物研究所天然药物化学研究室工作,先后任副研究员、研究员、博士生导师。已承担和参与科研课题15项,包括承担国家自然科学基金面上项目、参加国家自然科学基金重点项目和国际合作项目以及国家创新药物研究重大专项等。在国内外发表研究论文110篇,申请国内和国际发明专利11项,获国内专利授权5项,PCT专利授权1项。已招收博士研究生10人、博士生毕业7人,招收硕士研究生14人、硕士生毕业12人。主编出版专著1部,参编专著3部。

 

联系方式:

电话: 010-83172503(办) 

Email: qinhailin@imm.ac.cn

 

专业研究领域:

药物化学研究:活性天然产物的合成和成药性导向的结构多样性修饰研究

研究方向:

(1) 靶向x-盒结合蛋白-1(XBP1)激动剂及抑制剂的合成和构效关系研究;

(2) XBP1为靶点的创新药物研究

 

代表性论文:

1. Meng Xie, Hai-Jing Zhang, An-Jun Deng, Lian-Qiu Wu*, Zhi-Hui Zhang, Zhi-Hong Li, Wen-Jie Wang, and Hai-Lin Qin*. Synthesis and structure-sctivity relationships of N-dihydrocoptisine-8-ylidene aromatic amines and N-dihydrocoptisine-8-ylidene aliphatic amides as anti-ulcerative colitis agents targeting XBP1. Journal of Natural Products. 2016, 79, 775-783. DOI: 10.1021/acs.jnatprod.5b00807.

2. Zhi-Hui Zhang, Jing Li, Hai-Jing Zhang, An-Jun Deng, Lian-Qiu Wu*, Zhi-Hong Li, Hong-Rui Song, Wen-Jie Wang, Hai-Lin Qin*. Versatile methods for synthesizing organic acid salts of quaternary berberine-type alkaloids as anti-ulcerative colitis agents, J. Asian Nat. Prod. Res, 2016, 18, DOI: 10.1080/10286020.2016.1171760.

3. Dan Zhang, An-Jun Deng, Lin Ma, Xue-Fu You, Zhi-Hui Zhang, Zhi-Hong Li, Jian-Dong Jiang, Hai-Lin Qin. N-Substituted acetamide glycosides from the stems of Ephedra sinica, Phytochemistry Letters, 2015, 12, 320-327.

4. Zhi-Hui Zhang, Hai-Jing Zhang, An-Jun Deng, Bo Wang, Zhi-Hong Li, Yang Liu, Lian-Qiu Wu, Wen-Jie Wang, and Hai-Lin Qin. Synthesis and structure-activity relationships of quaternary coptisine derivatives as potential anti-ulcerative colitis agents. Journal of Medicinal Chemistry. 2015, 58, 7557-7571.

5. Jin Ren, Yan-Gai Wang, Ai-Guo Wang, Lian-Qiu Wu, Hai-Jing Zhang, Wen-Jie Wang, Ya-Lun Su, and Hai-Lin Qin. Cembranoids from the gum resin of Boswellia carterii as potential anti-ulcerative colitis agents. Journal of Natural Products. 2015, 78, 2322-2331.

6. Zhi-Hui Zhang, An-Jun Deng, Lian-Qiu Wu, Lian-Hua Fang, Jin-Qian Yu, Zhi-Hong Li, Tian-Yi Yuan, Wen-Jie Wang, Guan-Hua Du, Hai-Lin Qin*. Syntheses and structure–activity relationships in cytotoxicities of 13-substituted quaternary coptisine derivatives, European Journal of Medicinal Chemistry, 2014, 86, 542-549.

7. Zhi-Hui Zhang, Lian-Qiu Wu, An-Jun Deng, Jin-Qian Yu, Zhi-Hong Li, Hai-Jing Zhang, Weng-Jie Wang, Hai-Lin Qin*. New synthetic method of 8-oxocoptisine starting from natural quaternary coptisine as anti-ulcerative colitis agent, J. Asian Nat. Prod. Res, 2014, 16(8), 841-846.

8. Yong Yu, An-Jun Deng, Zhi-Hong Li, Ai-Lin Liu, Lin Ma, Zhi-Hui Zhang, Xiu-Li Wang, Gu-Hua Du, Hai-Lin Qin*. New Stemona alkaloids from the roots of Stemona tuberose, Magn. Reson. Chem. 2014, 52, 719-728.

9. Jin-Qian Yu, An-Jun Deng, Hai-Lin Qin*. Distinctive features of chemical composition from Bupleurum chinense applicable to original authentication, Anal. Methods, 2014,6, 1067-1075.

10. Hai-Yan Zhang, Tian-Zeng Zhao*, Jian-Jun Dong, Rong-Feng Chen, Zhi-Hong Li, Hailin Qin*. Four new sesquiterpene polyol esters from Celastrus angulatus, Phytochemistry Letters, 2014, 7, 101-106.

11. Jin-Qian Yu, An-Jun Deng, Lian-Qiu Wu, Zhi-Hui Zhang, Yang Liu, Wen-Jie Wang, Hai-Lin Qin*. Osteoclast-inhibiting saikosaponin Dderivertives from Bupleurum chinense, Fitoterapia, 2013,85, 101-108.

12. Jin-Qian Yu, An-Jun Deng, Hai-Lin Qin*. Nine new steroidal glycosides from the roots of Cynanchum stauntonii, Steroids, 2013,78(1):79-90.

13. Qiong Zhou, An-Jun Deng, Hai-Lin Qin*. Two new quaternary protoberberine alkaloids from Corydalis yanhusuo, J. Asian Nat. Prod. Res., 2012145):476-481.

14. Bo Liu, An-Jun Deng, Jin-Qian Yu, Ai-Lin Liu, Guan-Hua Du, Hai-Lin Qin*. Chemical constituents of the whole plants of Elsholtzia rugulosa, J. Asian Nat. Prod. Res.,2012142):89-96.

15. Shi-Hui Shu, An-Jun Deng, Zhi-Hong Li, Hai-Lin Qin*. Bioactive biphenyl dimers from the heartwood of Caesalpinia sappan, Fitoterapia, 2011, 82, 762-766.

16. Anjun Deng, Hailin Qin*. Cytotoxic dihydrobenzophenanthridine alkaloids from the roots of Macleaya microcarpa. Phytochemistry2010, 71(7) : 815-821.

17. Jian-Long Sun, An-Jun Deng, Yan Li, Zhi-Hong Li, Hui Chen, and Hai-Lin Qin.* First example of diterpenoids from 14,15-cyclopimarane in the roots of Linum usitatissimum Helvitica Chimica Acta, 2009, 92 (12): 2746-2753.

18. Dongmin Su, Jinglan Han, Shishan Yu, Hailin Qin*. Assessment of 1HNMR spectroscopy for specific metabolite fingerprinting of Angelica sinensis. Natural Product Communications20083(5):727-730.

19. Peng Wang, Ai-Lin Liu, Zheng An, Zhi-Hong Li, Guan-Hua Du, Hai-Lin Qin*. Novel alkaloids from the roots of Stemona sessilifolia, Chemistry & Biodiversity, 2007, 4(3): 523-530.

20. Jun-Rong Yang, Zheng An, Zhi-Hong Li, Song Jing, Hai-Lin Qin*. Sesquiterpene coumarins from the roots of Ferula sinkiangensis and Ferula teterrima, Chem. Pharm. Bull., 2006,56(11): 1595-1598.

21. Hai-Lin Qin*, Zhi-Hong Li. Clerodane-type diterpenoids from Nannoglottis ravida. Phytochemistry, 2004, 65(18):2533-2537.

22. Peng Wang, Hai-Lin Qin*, Ling Zhang, Zhi-Hong Li, Ying-Hong Wang, Hai-Bo Zhu. Steroids from the roots of Cynanchum stauntonii, Planta Med, 2004, 70: 1075-1079.

 

 

 

 

 

 

 

 

 

 

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