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陈乃宏

时间:2018/4/9 来源: 阅读:46433次


陈乃宏

 

陈乃宏  博士,研究员,博士生导师,

联系方式 电话010-63165177、邮箱: chennh@imm.ac.cn

 

兼任:中国医学科学院  神经科学中心副主任

中国药理学会副秘书长

中国药理学会 神经精神药理专业委员会 副主任委员

中国药理学会 补益药药理专业委员会 主任委员

北京市药理学会 神经精神药理专业委员会 主任委员

世界中医药联合会网络药理学会副理事长

全国中医药高等教育学会中药教育研究会副理事长

中国民族医药协会 精准医学专业委员会副会长

《神经药理学报》副主编

 

教育背景及工作经历

1993.10―          考取国费奖学金 赴日攻读博士

1997.03―         日本 国立 琦玉大学 获博士学位(M.D./Ph. D)

1997.04―2000.07  日本 三菱公司 生命科学研究所 博士后 / 外国人研究员

2000.07―2001.09  日本 理化研究所 前沿研究部门 研究员

2002.09―2004.10  日本 北里大学 医学院 客座教授(Visiting Professor

2001.09至今     引进归国就职于中国医学科学院 药物研究所研究员,博导

2013.05―至今     中国医学科学院神经科学中心 副主任

2014.10―至今     湖南中医药大学药学院院长

 

专业研究方向领域

本课题组主要从事神经药理学、神经分子生物学、中药药理学、神经系统疾患及炎症相关疾患的创新药物开发及机理研究。主要研究内容包括:

1、抗神经退行性疾病(PD/AD)创新药物研发及机制分析;

2、抗脑缺血创新药物研发及机制研究;

3、基于CKLF1为靶点的创新药物研发及机制分析;

4、抗抑郁症创新药物研发及机制分析;

5、荧光可视化技术在神经精神系统药物研究中的应用;

6、天然产物及中药创新药物的发现及作用机制研究。

 

承担的课题

近年来课题组主持和参与的国内外科研项目60余项,其中国际合作项目2项,国家级科研项目35项,省部级科研项目14项,所院校级科研项目13项。包括主持国家自然基金委重点项目、联合基金重点项目、面上项目,国家科技部十一五十三五新药创制重大专项,教育部博士点基金重点项目等课题,北京市自然基金委-重点项目;子课题主持或参与十二五国家科技攻关项目、国家科技部973项目、国家科技部863项目、国家自然基金委生物小分子重大项目、日本学术振兴会、日中医学会等科研项目的研究。主编和参与学术专著近20部,申请专利12项,授权专利3项,参与完成的项目曾获得中华医学科技奖二等奖(2010年和2012年各一项),及北京市科学技术奖二等奖(2011年)、三等奖(2012年)各一项。以通讯作者发表文章200余篇。

 

近年发表论文

近年发表SCI文章如下:

1. Zhang Z#, Chu SF#, Wang SS, Jiang YN, Gao Y, Yang PF, Ai QD, Chen NH*. RTP801 is a critical factor in the neurodegeneration process of A53T alpha-synuclein in a mouse model of Parkinson's disease under chronic restraint stress. Br J Pharmacol. 2018, 175(4): 590-605.

2. Ren Q#, Wang ZZ, Chu SF, Xia CY, Chen NH*. Gap junction channels as potential targets for the treatment of major depressive disorder. Psychopharmacology (Berl) 2018, 235(1):1-12. 

3. Chen C#, Chu SF, Liu DD, Zhang Z, Kong LL, Zhou X, Chen NH*. Chemokines play complex roles in cerebral ischemia. Neurochem Int. 2018, 112:146-158.

4. Liu DD#, Chu SF, Chen C, Yang PF, Chen NH*, He X*. Research progress in stroke-induced immunodepression syndrome(SIDS) and stroke-associated pneumonia(SAP). Neurochem Int. 2018, 6(114): 42-54.

5. Wen L# ,Zhang QS, Heng Y, Chen Y, Wang S, Yuan YH*, Chen NH*. NLRP3 inflammasome activation in the thymus of MPTP-induced Parkinsonian mouse model. Toxicol Lett. 2018, 5(288):1-8.

6. Chu SF#, Zhang Z#, Zhang W, Zhang MJ, Gao Y, Han N, Zuo W, Huang JY, Chen NH*. Upregulating the Expression of Survivin-HBXIP Complex Contributes to the Protective Role of IMM-H004 in Transient Global Cerebral Ischemia/Reperfusion. Mol Neurobiol. 2017 Jan;54(1):524-540.

7. Xia CY#, Wang ZZ, Zhang Zhao, Chen J, Wang YY, Lou YX, Gao Y, Luo P, Ren Q, Du GH, Chen NH*. Corticosterone impairs gap junctions in the prefrontal cortical and hippocampal astrocytes via different mechanisms. Neuropharmacology. 2017 Dec 6;131:20-30.

8. Jin C#, Wang ZZ, Zhou H, Lou YX, Chen J, Zuo W, Tian MT, Wang ZQ, Du GH, Kawahata I, Yamakuni T, Zhang Y, Chen NH*, Zhang DS*. Ginsenoside Rg1-induced antidepressant effects involve the protection of astrocyte gap junctions within the prefrontal cortex. Prog Neuropsychopharmacol Biol Psychiatry. 2017 Apr 3;75:183-191.

9. Zhang QS#, Heng Y, Chen Y, Luo P, Wen L, Zhang Z, Yuan YH*, Chen NH*. A Novel Bibenzyl Compound (20C) Protects Mice from 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine/Probenecid Toxicity by Regulating the a-Synuclein–Related Inflammatory Response. J Pharmacol Exp Ther. 2017 Nov;363(2):284-292.

10. Zhang QS#, Heng Y, Yuan YH*, Chen NH*. Pathological a-synuclein exacerbates the progression of Parkinson’s disease through microglial activation. Toxicol Lett. 2017 Jan 4;265:30-37.

11. Zhang XL#, Yuan YH, Shao QH, Wang ZZ, Zhu CG, Shi JG, Ma KL, Yan X, Chen NH*. DJ-1 regulating PI3K-Nrf2 signaling plays a significant role in bibenzyl compound 20C-mediated neuroprotection against rotenone-induced oxidative insult. Toxicol Lett. 2017 Apr 5;271:74-83. 

12. Liu DD#, Song XY, Yang PF, Ai QD, Wang YY, Feng XY, He X, Chen NH*. Progress in Pharmacological Research of chemokine like factor 1 (CKLF1). Cytokine. 2017 Dec 21;102:41-50.

13. Gao Y#, Chu SF, Zhang Z, Zuo W, Xia CY, Ai QD, Luo P, Cao P, Chen NH*. Early stage functions of mitochondrial autophagy and oxidative stress in acetaminophen-induced liver injury. J Cell Biochem. 2017 Oct;118(10):3130-3141.

14. Ren Q#, Wang ZZ, Chu SF, Xia CY, Chen NH*. Gap junction channels as potential targets for the treatment of major depressive disorder. Psychopharmacology (Berl) 2018, 235(1):1-12. 

15. Zhang QS#, Heng Y, Mou Z, Huang JY, Yuan YH*, Chen NH*. Reassessment of subacuteMPTP-treated mice as animal model of Parkinson's disease. Acta Pharmacol Sin. 2017 Oct;38(10):1317-1328.

16. Yang PF#, Song XY, Zeng T, Ai QD, Liu DD, Zuo W, Zhang S, Xia CY, He X, Chen NH*. IMM-H004, a coumarin derivative, attenuated brain ischemia/reperfusion injury and subsequent inflammation in spontaneously hypertensive rats through inhibition of VCAM-1 . RSC Advances 2017; 7: 27480–27495.

17. Chen J#, Wang ZZ, Zhang S, Ai QD, Chu SF, Chen NH*. Possible target-related proteins of stress-resistant rats suggested by label-free protemic analysis. RSC Advances 2017; 7: 40957-40964.

18. Gao Y#, Chu SF, Zhang Z, Chen NH*. Hepataprotective effects of ginsenoside Rg1 – A review. J Ethnopharmacol. 2017 Jul 12;206:178-183.

19. Xia CY#, Chu SF, Zhang S, Gao Y, Ren Q, Lou YX, Luo P, Tian MT, Wang ZQ, Du GH, Tomioka Y, Yamakuni T, Zhang Y, Wang ZZ*, Chen NH*. Ginsenoside Rg1 alleviates corticosterone-induced dysfunction of gap junctions in astrocytes.J Ethnopharmacol. 2017 Aug 17;208:207-213.

20. Gao Y#, Chu SF, Shao QH, Zhang MJ, Xia CY, Wang YY, Li YT, Lou YX, Huang HY, Chen NH*. Antioxidant activities of ginsenoside Rg1 against cisplatin-induced hepatic injury through Nrf2 signaling pathway in mice. Free Radic Res. 2017 Jan;51(1):1-13.

21. Mou Z#, Huang Q#, Chu SF, ZhangMJ, Hu JF, Chen NH*, Zhang JT, Antidepressive effects of ginsenoside Rg1 via regulation of HPA and HPG axis. Biomed Pharmacother. 2017 Aug;92:962-971. 

22. Shao QH#, Zhang XL, Yang PF, Yuan YH*,Chen NH*Amyloidogenic proteins associated with neurodegenerative diseases activate the NLRP3 inflammasome. Int Immunopharmacol. 2017 Aug;49:155-160.

23. Niu F#, Song XY#, Hu JF, Zuo W, Kong LL, Wang XF, Han N, Chen NH*, IMM-H004, A New Coumarin Derivative, Improved Focal Cerebral Ischemia via Blood–Brain Barrier Protection in Rats.J Stroke Cerebrovasc Dis. 2017 Oct;26(10):2065-2073.

24. Zuo W#, Yang PF, Chen J, Zhang Z, Chen NH*. Drp-1, a potential therapeutic target for brain ischemic stroke. Br J Pharmaco 2016; 173(10): 1665-1677.

25. Zhang Z#, Chu SF, Mou Z, Gao Y, Wang ZZ, Wei GN, Chen NH*. Ganglioside GQ1b induces dopamine release through the activation of Pyk2. Mol Cell Neurosci 2016; 71: 102-111.

26. Heng Y#, Zhang QS, Mu Z, Hu JF, Yuan YH*, Chen NH*.Ginsenoside Rg1 attenuates motor impairment and neuroinflammation in the MPTP-probenecid-induced parkinsonism mouse model by targeting α-synuclein abnormalities in the substantia nigra. Toxicol Lett 2016; 243(2016): 7-21.

27. Chen J#, Wang ZZ, Zuo W, Zhang S, Chu SF, Chen NH*.Effects of chronic mild stress on behavioral and neurobiological parameters-Role of glucocorticoid. HormBehav 2016; 78: 150-159.

28. Zhang S#, Song XY, Xia CY, Ai QD, Chen J, Chu SF, He WB, Chen NH*. Effects of cerebral glucose levels in infarct areas on stroke injury mediated by blood glucose changes. RSC Advances 2016; 6: 93815–93825.

29. Song XY#, Wang YY, Chu SF, Hu JF, Yang PF, Zuo W, Song LK, Zhang S, Chen NH*. IMM-H004, a new coumarin compound, attenuates okadaic acid-induced spatial memory impairmentin rats. Acta Pharmacol Sin 2016; 37(4): 444-452.

30. Huang JY#, Yuan YH,Yan JQ, Wang YN, Chu SF, Zhu CG, Guo QL, Shi JG, Chen NH*. 20C, a bibenzyl compound isolated from Gastrodiaelata, protects PC12 cells against rotenone-induced apoptosis via activation of the Nrf2/ARE/HO-1 signaling pathway. Acta Pharmacol Sin 2016; 37(6): 731-740.

31. Zhou H#, Xue W, Chu SF, Wang ZZ, Li CJ, Jiang YN, Luo LM, Luo P, Li G, Zhang DM, Chen NH*. Polygalasaponin XXXII, a triterpenoid saponin from Polygalae Radix, attenuates scopolamine-induced cognitive impairments in mice. Acta Pharmacol Sin 2016; 37(8): 1045-1053.

32. Zhang S#, Shao SY, Song XY, Xia CY, Yang YN, Zhang PC*, Chen NH*. Protective effects of Forsythia suspense extract with antioxidant and anti-inflammatory properties in a model of rotenone induced neurotoxicity. Neurotoxicology 2016; 52: 72-83.

33. Chen J#, Wang ZZ, Zhang S, Zuo W, Chen NH*. Does mineralocorticoid receptor play a vital role in the development of depressive disorder? Life Sci 2016; 152:76-81.

34. Huang JY#, Ma YZ, Yuan YH, Zuo W, Chu SF, Liu H, Du GH, Zhang DM, Chen NH*. Claulansine F promoted the neuronal differentiation of neural stem and progenitor cells through Akt/GSK-3β/β-catenin pathway. Eur J Pharmacol 2016; 786: 72-84.

35. Xia CY#, Zhang S, Chu SF, Wang ZZ, Song XY, Zuo W, Gao Y, Yang PF, Chen NH*. Autophagic flux regulates microglial phenotype according to the time of oxygen-glucose deprivation/reperfusion. Int Immunopharmacol 2016; 39:140-148.

36. Kong LL#, Wang ZY, Hu JF, Yuan YH, Li H, Chen NH*. Inhibition of chemokine-like factor 1 improves blood-brain barrier dysfunction in rats following focal cerebral ischemia. Neurosci Lett 2016; 627: 192-198.

37. Gao Y#, Chu SF, Xia CY, Zhang Z, Zhang S, Chen NH*. Rg1 Attenuates alcoholic hepatic damage through regulating AMP-activated protein kinase and nuclear factor erythroid 2-related factor 2 signal pathways. J Asian Nat Prod Res 2016; 18(8): 765-778.

38. Zhang S#, Shao SY, Song XY, Xia CY, Yang YN, Zhang PC*, Chen NH*. Protective effects of Forsythia suspense extract with antioxidant and anti-inflammatory properties in a model of rotenone induced neurotoxicity. Neurotoxicology 2015; 52:72-83.

39. Zuo W#, Zhang W#, Han N, Chen NH*. Compound IMM-H004, a Novel Coumarin Derivative, Protects against CA1 Cell Loss and Spatial Learning Impairments Resulting from Transient Global Ischemia. CNS Neurosci Ther 2015; 21: 280-288.

40. Yuan YH#, Yan WF, Sun JD, Huang JY, Mou Z, Chen NH*. The molecular mechanism of rotenone-induced a-synuclein aggregation: Emphasizing the role of the calcium/GSK3β pathway. Toxiol Lett 2015; 233(2): 163-171.

41. Song LK#, Ma KL, Yuan YH, Mu Z, Song XY, Niu F, Han N, Chen NH*. Targeted Overexpression of α-Synuclein by rAAV2/1 Vectors Induces Progressive Nigrostriatal Degeneration and Increases Vulnerability to MPTP in Mouse. PLoS One 2015; 10(6): e0131281.

42. Liu Y#, Sun JD, Song LK, Li J, Chu SF, Yuan YH, Chen NH*. Environment-contact administration of rotenone: A new rodent model of Parkinson’s disease. Behav Brain Res 2015; 294: 149-161.

43. Gao Y#, Chu SF, Li JW, Li JP, Zhang Z, Xia CY, Heng Y, Zhang MJ, Hu JF, Wei GN, Li YT, Chen NH*. Anti-inflammatory function of ginsenoside Rg1 on alcoholic hepatitis through glucocorticoid receptor related nuclear factor-kappa B pathway. J Ethnopharmacol 2015; 173: 231-240.

44. Gao Y#, Chu SF, Li JP, Zhang Z, Yan JQ, Wen ZL, Xia CY, Mou Z, Wang ZZ, He WB, Guo XF, Wei GN, Chen NH*. Protopanaxtriol protects against 3-nitropropionic acid-induced oxidative stress in a rat model of Huntington's disease. Acta Pharmacol Sin 2015; 36(3): 311-322.

45. Song XY#, Xu S#, Hu JF, Tang J, Chu SF, Liu H, Han N, Li JW, Zhang DM, Li YT*, Chen NH*. Piperine prevents cholesterol gallstones formation in mice. Eur J Pharmacol 2015; 751: 112-117.

46. Xia CY#, Zhang S, Gao Y, Wang ZZ, Chen NH*. Selectively modulate microglia polarization to M2 phenotype for stroke treatment. Int Immunopharmacol 2015; 25(2015): 377-382.

47. Yan WF#, Shao QH, Zhang DM, Yuan YH*, Chen NH*. The molecular mechanism of polygalasaponin F-mediated decreases in TNF α: emphasizing the role of the TLR4-PI3K/AKT-NF-κB pathway. J Asian Nat Prod Res 2015; 17(6): 662-670.

48. He WB#, Zhang JL, Chen NH*. Protein kinase-based neural signaling pathways for ginsenosides: a retrospective review. J Tradit Chin Med 2015; 35(3): 349-354.

49. Kong LL#, Wang ZY, Han N, Zhuang XM, Wang ZZ, Li H*, Chen NH*. Neutralization of chemokine-like factor 1, a novel C-C chemokine, protects against focal cerebral ischemia by inhibiting neutrophil infiltration via MAPK pathways in rats. J Neuroinflammation 2014; 11:112.

50. Yan JQ#, Yuan YH, Gao YN, Huang JY, Ma KL, Gao Y, Zhang WQ, Guo XF, Chen NH*. Overexpression of Human E46K Mutant alpha-Synuclein Impairs Macroautophagy via Inactivation of JNK1-Bcl-2 Pathway. Mol Neurobiol 2014; 50(2): 685-703.

51. Zuo W#, Zhang S, Xia CY, Guo XF, He WB, Chen NH*. Mitochondria autophagy is induced after hypoxic/ischemic stress in a Drp1 dependent manner: The role of inhibition of Drp1 in ischemic brain damage. Neuropharmacology 2014; 86C: 103-115.

52. Ma KL#, Song LK, Yuan YH, Zhang Y, Han N, Gao K, Chen NH*. The nuclear accumulation of alpha-synuclein is mediated by importin alpha and promotes neurotoxicity by accelerating the cell cycle. Neuropharmacology 2014; 82: 132-142.

53. Zhang Z#, Zhang Y, Mou Z, Chu SF, Chen XY, He WB, Guo XF, Yuan YH, Takahashi M, Chen NH*. Tyrosine 402 phosphorylation of pyk2 is involved in ionomycin-induced neurotransmitter release. PLoS One 2014; 9: e94574.

54. Zuo W#, Chen J, Zhang S, Tang J, Liu H, Zhang DM, Chen NH*. IMM-H004 prevents toxicity induced by delayed treatment of tPA in a rat model of focal cerebral ischemia involving PKA-and PI3K-dependent Akt activation. Eur J Neurosci 2014; 39: 2107-2118. 

55. Kong LL#, Wang ZY, Hu JF, Yuan YH, Han N, Li H, Chen NH*. Inhibition of chemokine-like factor 1 protects against focal cerebral ischemia through the promotion of energy metabolism and anti-apoptotic effect. Neurochem Int 2014; 76C: 91-98.

56. Zhang S#, Zuo W, Guo XF, He WB, Chen NH*. Cerebral glucose transporter: the possible therapeutic target for ischemic stroke. Neurochem Int 2014; 70: 22-29.

57. Zhang S#, He WB, Chen NH*. Causes of death among persons who survive an acute ischemic stroke. Curr Neurol Neurosci Rep 2014; 14(8): 467.

58. Gao Y#, Chu SF, Li JP, Zuo W, Wen ZL, He WB, Yan JQ, Chen NH*. Do glial cells play an anti-oxidative role in Huntington's disease? Free Radic Res 2014; 48(10): 1135-1144.

59. Li JP#, Gao Y, Chu SF, Zhang Z, Xia CY, Mou Z, Song XY, He WB, Guo XF, Chen NH*. Nrf2 pathway activation contributes to anti-fibrosis effects of ginsenoside Rg1 in a rat model of alcohol- and CCl-induced hepatic fibrosis. Acta Pharmacol Sin 2014; 35: 1031-1044.

60. Song XY#, Hu JF#, Sun MN, Li ZP, Zhu ZX, Song LK, Yuan YH, Liu G, Chen NH*. IMM-H004, a novel coumarin derivative compound, attenuates the production of inflammatory mediatory mediators in lipopolysaccharide-activated BV2 microglia. Brain Res Bull 2014; 106: 30-38.

61. Ji HJ#, Wang DM, Hu JF, Sun MN, Li G, Li ZP, Wu DH, Liu G, Chen NH*. IMM-H004, a novel courmarin derivative, protects against oxygen-and glucose-deprivation/restoration-induced apoptosis in PC12 cells. Eur J Pharmacol 2014; 723: 259-266.

62. Ma KL#, Song LK#, Yuan YH, Zhang Y, Yang JL, Zhu P, Chen NH*. alpha-Synuclein is prone to interaction with the GC-box-like sequence in vitro. Cell Mol Neurobiol 2014; 34: 603-609.

63. Li G* #, Li GY, Wang ZZ, Ji HJ, Wang DM, Hu JF, Yuan YH, Liu G, Chen NH*. The chemokine-like factor 1 induces asthmatic pathological change by activating nuclear factor-kappaB signaling pathway. Int Immunopharmacol 2014; 20: 81-88.

64. Li ZP#, Ji HJ, Song XY, Hu JF, Han N, Chen NH*. Osthole attenuates the development of carrageenan-induced lung inflammation in rats. Int Immunopharmacol 2014; 20: 33-36.

65. Li BY#, Yuan YH, Zhang WQ, He WB, Hu JF, Chen NH*. Flavin-containing monooxygenase, a new clue of pathological proteins in the rotenone model of parkinsonism. Neurosci Lett 2014; 566: 11-16.

66. Wang ZZ#, Yuan YH, Zhang Y, Wang XF, Chu SF, Han N, Chen NH*. Chemokine-like factor 1 promotes the migration of rat primary cortical neurons by the induction of actin polymerization. Neuroreport 2014; 25(15): 1221-1226.

67. Wu MM#, Yuan YH#, Chen J, Li CJ, Zhang DM, Chen NH*. Polygalasaponin F against rotenone-induced apoptosis in PC12 cells via mitochondria protection pathway. J Asian Nat Prod Res 2014; 16: 59-69.

68. Wei W#, Yuan YH#, Gao YN, Yan WF, Li CJ, Zhang DM, Chen NH*. Polygalasaponin F inhibits secretion of inflammatory cytokines via NF-kappaB pathway regulation. J Asian Nat Prod Res 2014; 16(8): 865-875.

69. Sun MN#, Hu JF#, Song XY, Wu DH, Kong LL, Xia YP, Wang DM, Wang Y*, Chen NH

*, Liu G*. Coumarin derivatives protect against ischemic brain injury in rats. Eur J Med Chem 2013; 67: 39-53.

70. Song XY#, Hu JF, Sun MN, Li ZP, Wu DH, Ji HJ, Yuan YH, Zhu ZX, Han N, Liu G, Chen NH*. IMM-H004, a novel coumarin derivative compound, protects against amyloid beta-induced neurotoxicity through a mitochondrial-dependent pathway. Neuroscience 2013; 242: 28–38.

71. Li JW#, Ning N#, Ma YZ, Zhang R, Tan F, Chen NH*. Claulansine F suppresses apoptosis induced by sodium nitroprusside in PC12 cells. Free Radic Res 2013; 47(6-7): 488-497

72. Ma KL#, Song LK, Long WA, Yuan YH, Zhang Y, Song XY, Niu F, Han N, Chen NH*. Deletion in exon 5 of the SNCA gene and exposure to rotenone leads to oligomerization of α-synuclein and toxicity to PC12 cells. Brain Res Bull 2013; 90: 127-131.

73. Li ZP#, Hu JF, Sun MN, Song XY, Li G, Liu Y, Li GY, Ji HJ, Liu G, Chen NH*. In vitro and in vivo anti-inflammatory effects of IMMLG5521, a coumarin derivative. Int Immunopharmacol 2013; 17: 400-403.

74. Song XY#, Hu JF, Chu SF, Zhang Z, Xu S, Yuan YH, Han N, Liu Y, Niu F, He X, Chen NH*. Ginsenoside Rg1 attenuates okadaic acid induced spatial memory impairment by the GSK3β/tau signaling pathway and the Aβ formation prevention in rats. Eur J Pharmacol 2013; 710(1-3): 29-38.

75. Yuan YH#, Sun JD, Wu MM, Hu JF, Peng SY, Chen NH*. Rotenone Could Activate Microglia Through NF-κB Associated Pathway. Neurochem Res 2013; 38: 1553-1560.

76. Ma YZ#, Ning N, He WB, Li JW, Hu JF, Chu SF, Chen NH*. Claulansine F promotes neuritogenesis in PC12 cells via the ERK signaling pathway. Acta Pharmacol Sin 2013; 34: 1499-507.

77. Zuo W#, Zhang W, Chen NH*. Sexual dimorphism in cerebral ischemia injury. Eur J Pharmacol 2013; 711: 73-79.

78. Sun JD#, Liu Y, Yuan YH, Li J, Chen NH*. Gap Junction Dysfunction in the Prefrontal Cortex Induces Depressive-Like Behaviors in Rats. Neuropsychopharmacology 2012; 37(5): 1305-1330.

79. Ning N#, Hu JF, Sun JD, Han N, Zhang JT*, Chen NH*. (-) Clausenamide facilitates synaptic transmission at hippocampal Schaffer collateral-CA1 synapses. Eur J Pharmacol 2012; 682: 50-55.

80. Li ZP#, Hu JF, Sun MN, Ji HJ, Chu SF, Liu G, Chen NH*. Anti-inflammatory effect of IMMLG5521, a coumarin derivative, on Sephadex-induced lung inflammation in rats. Int Immunopharmacol 2012; 14: 145–149.

81. Ning N#, Hu JF, Yuan YH, Zhang XY, Dai JG, Chen NH*. Huperzine A derivative M3 protects PC12 cells against sodium nitroprusside-induced apoptosis. Acta Pharmacol Sin 2012; 33(1): 34-40.

82. Sun F#, Sun JD, Han N, Li CJ, Yuan YH, Zhang DM, Chen NH*. Polygalasaponin F induces long-term potentiation in adult rat hippocampus via NMDA receptor activation. Acta Pharmacol Sin 2012; 33(4): 431-437.

83. Kong LL#, Hu JF, Zhang W, Yuan YH, Han N, Chen NH*. C19, a C-terminal peptide of chemokine-like factor 1, protects the brain against focal brain ischemia in rats. Neurosci Lett 2012; 508(1): 13–16.

84. Wang ZZ#, Zhang Y, Yuan YH, Chen NH*. Developmental expression of chemokine-like factor 1, a novel member of chemokines family, in postnatal rat cerebral cortex. Neurosci Lett 2012; 519: 51-55.

85. Ning N#, Sun JD, Du GH, Han N, Zhang JT, Chen NH*. (+)-epi-Clausenamide, but not (-)-epi-clausenamide, showed more potential than (-)-clausenamide on facilitating synaptic transmission in CA1 region of hippocampal synapses. Neurosci Lett 2012; 523(2): 99-103.

86. Hu JF#, Niu F#, Ning N, Duan WZ, Chu SF, Xue W, Yuan YH, Chen NH*, Zhang JT*. Activation of ERK1/2-CREB pathway during potentiating synaptic transmission of (-) clausenamide in rat dentate gyrus. J Asian nat Prod Res 2012; 14(3): 256-262.

87. Li BY#, Zhang Y, Yuan YH, Chen NH*. A new perspective in Parkinson's disease, chaperone-mediated autophagy. Parkinsonism Relat Disord 2011; 17: 231-235.

88. Hu JF#, Song XY, Chu SF, Chen J, Ji HJ, Chen XY, Yuan YH, Han N, Zhang JT, Chen NH*. Inhibitory effect of ginsenoside Rg1 on lipopolysaccharide-induced microglial activation in mice. Brain Res 2011; 1374: 8-14.

89. Li ZP#, Hu JF, Sun MN, Ji HJ, Zhao M, Wu DH, Li GY, Liu G, Chen NH*. Effect of compound IMMLG5521, a novel coumarin derivative, on carrageenan-induced pleurisy in rats. Eur J Pharmacol 2011; 661: 118-123.

90. Ma KL#, Yuan YH, Song LK, Han N, Chen NH*. Over-expression of α-synuclein 98 triggers intracellular oxidative stress and enhances susceptibility to rotenone. Neurosci Lett 2011; 491: 148-152.

91. Kong LL#, Hu JF, Zhang W, Yuan YH, Ma KL, Han N, Chen NH*. Expression of chemokine-like factor 1 after focal cerebral ischemia in the rat. Neurosci Lett 2011; 505: 14-18.

92. Li BY#, Yuan YH, Hu JF, Zhao Q, Zhang DM, Chen NH*. Protective effect of Bu-7, a flavonoid extracted from Clausena lansium, against rotenone injury in PC12 cells. Acta Pharmacol Sin 2011; 32: 1321-1326.

93. Li G#, Wang DM#, Sun MN, Li GY, Hu JF, Zhang Y, Yuan YH, Ji HJ, Chen NH*, and Gang Liu*. Discovery and Optimization of Novel 3-Piperazinylcoumarin Antagonist of Chemokine-like Factor 1 with Oral Antiasthma Activity in Mice. J Med Chem 2010; 53: 1741–1754.

94. Ji HJ#, Hu JF, Wang YH, Chen XY, Zhou R, Chen NH*. Osthole improves chronic cerebral hypoperfusion induced cognitive deficits and neuronal damage in hippocampus. Eur J Pharmacol 2010; 636: 96–101.

95. Liu ZJ#, Zhao M#, Zhang Y, Xue JF, Chen NH*. Ginsenoside Rg1 promotes glutamate release via a calcium/calmodulin-dependent protein kinase II-dependent signaling pathway. Brain Res 2010; 1333: 1-8.

96. Wang ZZ#, Li G, Chen XY, Zhao M, Yuan YH, Wang XL, Chen NH*. Chemokine-like factor 1, a novel cytokine, induces nerve cell migration through the non-extracellular Ca2+-dependent tyrosine kinases pathway. Brain Res 2010; 1308: 24-34.

97. Zhang W#, Kudo H, Kawai K, Fujisaka S, Usui I, Sugiyama T, Tsukada K, Chen NH*, Takahara T*. Tumor necrosis factor-a accelerates apoptosis of steatotic hepatocytes from a murine model of non-alcoholic fatty liver disease. Biochem Biophys Res Commun 2010; 391: 1731-1736.

98. Yuan YH#, Sun JD, Zhao M, Hu JF, Wang XL, Du GH, Chen NH*. Overexpression of a-Synuclein Down-Regulates BDNF Expression. Cell Mol Neurobiol 2010; 30: 939-946.

99. Hu JF#, Chu SF, Ning N, Yuan YH, Xue W, Chen NH*, Zhang JT*. Protective effect of (−)clausenamide against A-induced neurotoxicity in differentiated PC12 cells. Neurosci lett 2010; 483: 78-82.

100. Wang YZ#, Wang YS#, Chu SF, Chen NH*, Zhang JT*. Protopanaxatriol metabolites identified by LC-MS/MS after oral administration in mice. Int J Clin Pharmacol Ther 2010; 48(4): 282-290.

 

 

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