English

设为首页 | 加入收藏 | 联系我们

首页 >> 研究生教育 >> 导师介绍 >> 博士生导师

张金兰

时间:2021/3/19 来源: 阅读:44990次


张金兰

 

张金兰 博士,研究员,博士研究生导师,北京协和医学院药物分析学系副系主任,药物分析研究室副主任。中国农工民主党党员,农工中央医卫委委员。1992年至今一直从事药物分析和药物代谢的研究工作,1995年以来作为课题负责人承担和完成了15余项国家和省部级研究课题,2009年度入选教育部新世纪优秀人才计划。

 

联系方式

Emailzhjl@imm.ac.cn,电话:010-83154880

 

教育背景

19927月毕业于北京医科大学,获理学学士学位;

19957月毕业于中国协和医科大学,获理学硕士学位;

20027月毕业于中国协和医科大学,获药物分析学博士学位。

 

工作经历

19999月至20027月在中国医学科学院药物研究所分析室工作,

任助研和副研究员。

20028月至20045月:在北京大学医学部药学院进行博士后研究工作。

20046月作为分析学科引进人才在中国医学科学院药物研究所药物分析

研究室工作,任副研究员和研究员。

 

专业研究领域

1. 药物分析新技术与方法研究;

2. 中草药有效成分分析和代谢研究;

3. 代谢组学/蛋白组学分析新技术研究和应用;

4. 新药质量标准和代谢研究。

 

发表论文

1. Menglin Li, Hao Zheng, Miao Lin, Wenwen Zhu, Jinlan Zhang*. Characterization of the protein and peptide of excipient zein by the multienzyme digestion coupled with nano-LC-MS/MS. Food Chemistry, 2020, 321: 126712.

 

2. Wenwen Zhu#, Menglin Li#, Jinlan Zhang*. Integrating Intact Mass Analysis and Middle-Down Mass Spectrometry Approaches to Effectively Characterize Trastuzumab and Adalimumab Structural Heterogeneity. Journal of Proteome Research, 2020. doi=10.1021/acs.jproteome.0c00373.

3. Zhe Wang#, Fan Zhang#, Wei Liu, Ning Sheng, Hua Sun*, Jinlan Zhang*. Impaired tricarboxylic acid cycle flux and mitochondrial aerobic respiration during isoproterenol induced myocardial ischemia is rescued by bilobalide[J]. Journal of Pharmaceutical Analysis, 2020. doi.org/10.1016/j.jpha.2020.08.008.

4. Ning Sheng#, Hao Zheng#, Min Li, Menglin Li, Zhe Wang, Ying Peng, Haibo Yu*, Jinlan Zhang*. 4,5 caffeoylquinic acid and scutellarin, identified by integrated metabolomics and proteomics approach as the active ingredients of Dengzhan Shengmai, act against chronic cerebral hypoperfusion by regulating glutamatergic and GABAergic synapses. Pharmacological Research, 2020, 152C, 104636.

5. Miao Lin , Xiong Chen , Zhe Wang , Dongmei Wang **, Jin-Lan Zhang *Global profiling and identification of bile acids by multi-dimensional data mining to reveal a way of eliminating abnormal bile acidsAnalytica Chimica Acta10.1016/j.aca.2020.07.067.

6. Yu Tang, Xiong Chen, Dongmei Wang, Ruiping Zhang, Jinlan ZhangDiscover and identify unknown alkylation DNA adducts induced by sulfonates using prediction driven -MRM-profiling strategyTalanta 222 (2021) 121500.

7. Miao Lin , Zhe Wang , Dongmei Wang, Xiong Chen, Jin-Lan ZhangA mathematical model-assisted UHPLC-MS/MS method for global profiling and quantification of cholesteryl esters in hyperlipidemic golden hamsterAnalytical chemistry, 2019, 914504–4512.

8. Hu T, Jia ZX, Zhang JL., Strategy for Comprehensive Proling and Identication of Acidic Glycosphingolipids Using Ultra-High-Performance Liquid Chromatography Coupled with Quadrupole Time-of-Flight Mass Spectrometry, Analytical chemistry, 2017, 89, 78087816.

9. Sheng N., Zheng H., Xiao Y., Wang Z., Li ML, zhang JL., Chiral separation and chemical profile of Dengzhan Shengmai by integrating comprehensive with multiple heart-cutting two-dimensional liquid chromatography coupled with quadrupole time-of-flight mass spectrometry. Journal of Chromatography A, 2017151797-107.

10. Menglin Li, Ting Hu, Cai Tie, Liang Qu, Hao Zheng, Jinlan ZhangQuantitative Proteomics and Targeted Fatty Acids Analysis Reveal the Damage of Triptolide in Liver and Kidney. Proteomics, 2017, DOI: 10.1002/pmic.201700001

11. Tie C, Hu T, Jia ZX, Zhang JL. Derivatization Strategy for the Comprehensive Characterization of Endogenous Fatty Aldehydes Using HPLC-Multiple Reaction Monitoring. Analytical chemistry, 2016, 88,7762-7768.

12. Hu T, Tie C, Wang Z, Zhang JL. Highly Sensitive and Specific Derivatization Strategy to Profile and Quantitate Eicosanoids by UPLC-MS/MS. Analytica Chimica Acta, 2017,950,108-118.

13. Caihong Wang, Caisheng Wu, Lin Zhang, Jinlan Zhang*. Ultraperformance liquid chromatography-tandem mass spectrometry method for profiling ketolic and phenolic sex steroids using an automated injection program combined with diverter valve switch and step analysis. Analytical chemistry, 2016, 88, 7878-7884.

14. Tie, C.*, Hu, T, Jia, Z. X., Zhang, J. L.** , Automatic Identification Approach for High-Performance Liquid Chromatography-Multiple Reaction Monitoring Fatty Acid Global Profiling. Analytical chemistry , 2015, 87, 8181-8185.

15. Liang Qu, Yao Xiao, Zhixin Jia, Zhe Wang, Caihong Wang, Ting Hu, Caisheng Wu, Jinlan Zhang*. Comprehensive two-dimensional liquid chromatography coupled with quadrupole time-of-flight mass spectrometry for chemical constituents analysis of tripterygium glycosides tablets, Jinlan Zhang*. Journal of Chromatography A, 2015,38,1400, 65–73.

16. Cai, T.*, Ting, H., Jin-Lan, Z**. Novel identification strategy for ground coffee adulteration based on UPLC-HRMS oligosaccharide profiling. Food chemistry 2016, 190, 1046-1049.

17. Caihong Wang, Caisheng Wu, Jinlan Zhang*, Ying Jin. Systematic considerations for a multicomponent pharmacokinetic study of Epimedii wushanensis herba: From method establishment to pharmacokinetic marker selection. Phytomedicine, 2015, 22, 487-97.

18. Tie, C.*, Hu, T., Guo, B., & Zhang, J**. Novel strategy for herbal species classification based on UPLC-HRMS oligosaccharide profiling. J Pharm Biomed Anal, 2015, 111, 14-20.

19. Liang Qu, Feng Qu, Zhixin Jia, Caihong Wang, Caisheng Wu, Jinlan Zhang*. Integrated targeted sphingolipidomics and transcriptomics reveal abnormal sphingolipid metabolism as a novel mechanism of the hepatotoxicity and nephrotoxicity of triptolide, Journal of Ethnopharmacology, 201517028–38.

20. Cai Tie, Ting Hu, Xinxiang Zhang, Jiang Zhou, Jinlan Zhang. HPLC-MRM Relative Quantification analysis of Fatty Acids Based on a Novel Derivatization Strategy. Analyst, 2014, 139, 6154-6159.

21. Ying Jin, Cai-Sheng Wu, Jin-Lan Zhang, Ying-Fei LiA new strategy for the discovery of epimedium metabolites using high-performance liquid chromatography with high resolution mass spectrometryAnalytica Chimica Acta, 2013, 768, 111– 117.

 

专著

《固相萃取技术与应用》第二版,编委

《中国仿制药蓝皮书》2016版至2019版,参编

 

获奖情况

1. 1998年获中华人民共和国卫生部科学技术进步奖二等奖,获奖项目:藁本的化学研究,排名第六。

2. 2008年获中华人民共和国教育部自然科学奖一等奖,获奖项目:中药复杂体系成分分析及体内过程研究,排名第六

3. 2014年获中国药学会科学技术奖三等奖,获奖项目:临床常用药物中微量杂质检测和安全控制关键技术研究与应用,排名第四

4. 2018年获得中国分析测试协会科学技术奖一等奖,获奖项目:中草药成分及其代谢分析新方法和应用,排名第一

 

 

内部链接
相关链接