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张金兰

时间:2019/4/23 来源: 阅读:35925次


张金兰

 

张金兰 博士,研究员,博士研究生导师,北京协和医学院药物分析学系副系主任。1992年至今一致从事药物分析和药物代谢的研究工作,1995年以来作为课题负责人承担和完成了10余项国家和省部级研究课题,2009年度入选教育部新世纪优秀人才计划。

 

联系方式:Emailzhjl@imm.ac.cn

 

社会兼职

《中国药学》(英文版)编委,

《药物分析杂志》编委,

《质谱学报》编委,

Journal of Separation Science编委,

中国质谱学会常务理事,

全国生物计量技术委员会委员,

中国分析测试协会青年学术委员会顾问,

中华中医药学会中药资源分会委员,

中国医药生物技术协会药物分析技术分会常务委员,

中国实验室合格评定委员会(CNAS)实验室认可评审员,

国际反兴奋剂组织(WADA)实验室认可评审员。

 

学习经历

19927月毕业于北京医科大学(现北京大学医学部),获理学学士学位;

19957月毕业于中国协和医科大学(现北京协和医学院),获理学硕士学位;

20027月毕业于中国协和医科大学(现北京协和医学院),获药物分析学博士学位。

 

工作简历

19999月至20027月在中国医学科学院药物研究所分析室工作,任助研和副研究员。

20028月至20045月:在北京大学医学部药学院进行博士后研究工作。

20046月作为分析学科引进人才在中国医学科学院药物研究所药物分析研究室工作,任副研究员和研究员。

 

主要研究方向

1. 药物分析新技术与方法研究;

2. 中草药有效成分分析和代谢研究;

3. 代谢组学/脂质组学分析新技术研究和应用;

4. 新药质量标准和代谢研究。

 

近年来发表代表性文章

已发表SCI论文60余篇,近期发表代表性文章如下:

1.      Miao Lin , Zhe Wang , Dongmei Wang, Xiong Chen, Jin-Lan ZhangA mathematical model-assisted UHPLC-MS/MS method for global profiling and quantification of cholesteryl esters in hyperlipidemic golden hamsterAnalytical chemistry, 2019, 914504–4512

2.      Hu T, Jia ZX, Zhang JL., Strategy for Comprehensive Proling and Identication of Acidic Glycosphingolipids Using Ultra-High-Performance Liquid Chromatography Coupled with Quadrupole Time-of-Flight Mass Spectrometry, Analytical chemistry, 2017, 89, 7808−7816

3.      Sheng N., Zheng H., Xiao Y., Wang Z., Li ML, zhang JL., Chiral separation and chemical profile of Dengzhan Shengmai by integrating comprehensive with multiple heart-cutting two-dimensional liquid chromatography coupled with quadrupole time-of-flight mass spectrometry. Journal of Chromatography A, 2017151797-107.

4.      Menglin Li, Ting Hu, Cai Tie, Liang Qu, Hao Zheng, Jinlan ZhangQuantitative Proteomics and Targeted Fatty Acids Analysis Reveal the Damage of Triptolide in Liver and Kidney. Proteomics, 2017, DOI: 10.1002/pmic.201700001

5.      Tie C, Hu T, Jia ZX, Zhang JL. Derivatization Strategy for the Comprehensive Characterization of Endogenous Fatty Aldehydes Using HPLC-Multiple Reaction Monitoring. Analytical chemistry, 2016, 88,7762-7768.

6.      Hu T, Tie C, Wang Z, Zhang JL. Highly Sensitive and Specific Derivatization Strategy to Profile and Quantitate Eicosanoids by UPLC-MS/MS. Analytica Chimica Acta, 2017,950,108-118.

7.      Caihong Wang, Caisheng Wu, Lin Zhang, Jinlan Zhang*. Ultraperformance liquid chromatography-tandem mass spectrometry method for profiling ketolic and phenolic sex steroids using an automated injection program combined with diverter valve switch and step analysis. Analytical chemistry, 2016, 88, 7878-7884.

8.      Tie, C.*, Hu, T, Jia, Z. X., Zhang, J. L.** , Automatic Identification Approach for High-Performance Liquid Chromatography-Multiple Reaction Monitoring Fatty Acid Global Profiling. Analytical chemistry , 2015, 87, 8181-8185.

9.      Liang Qu, Yao Xiao, Zhixin Jia, Zhe Wang, Caihong Wang, Ting Hu, Caisheng Wu, Jinlan Zhang*. Comprehensive two-dimensional liquid chromatography coupled with quadrupole time-of-flight mass spectrometry for chemical constituents analysis of tripterygium glycosides tablets, Jinlan Zhang*. Journal of Chromatography A, 2015,38,1400, 65–73.

10.   Cai, T.*, Ting, H., Jin-Lan, Z**. Novel identification strategy for ground coffee adulteration based on UPLC-HRMS oligosaccharide profiling. Food chemistry 2016, 190, 1046-1049.

11.   Caihong Wang, Caisheng Wu, Jinlan Zhang*, Ying Jin. Systematic considerations for a multicomponent pharmacokinetic study of Epimedii wushanensis herba: From method establishment to pharmacokinetic marker selection. Phytomedicine, 2015, 22, 487-97.

12.   Tie, C.*, Hu, T., Guo, B., & Zhang, J**. Novel strategy for herbal species classification based on UPLC-HRMS oligosaccharide profiling. J Pharm Biomed Anal, 2015, 111, 14-20.

13.   Zhe Wang, Caisheng Wu, Gangli Wang, Qingsheng Zhang, Jinlan Zhang*. Novel strategy for the determination of illegal adulterants in health foods and herbal medicines using high-performance liquid chromatography with high-resolution mass spectrometry. Journal of Separation Science, 2015, 38, 925–935.

14.   Liang Qu, Feng Qu, Zhixin Jia, Caihong Wang, Caisheng Wu, Jinlan Zhang*. Integrated targeted sphingolipidomics and transcriptomics reveal abnormal sphingolipid metabolism as a novel mechanism of the hepatotoxicity and nephrotoxicity of triptolide, Journal of Ethnopharmacology, 201517028–38.

15.   Cai Tie, Ting Hu, Xinxiang Zhang, Jiang Zhou, Jinlan Zhang. HPLC-MRM Relative Quantification analysis of Fatty Acids Based on a Novel Derivatization Strategy. Analyst, 2014, 139, 6154-6159.

16.   Qiang Ren, Yingfei Li, Caisheng Wu, Caihong Wang, Ying Jin, Jinlan Zhang. Metabolism secondary metabolites isolatd from Tartary buckwheat and its extract. Food Chemistry, 2014, 154, 134-144.

17.   Feng Qu, Sujun Zheng, Caisheng Wu, Zhixin Jia, Jinlan Zhang, Zhongping Duan. Lipidomic profiling of plasma in patients with chronic hepatitis C infection. Analytical and bioanalytical chemistry, 2014, 406, 555-564.

18.   Jinfeng Hou, Qian Liu, Yingfei Li, Hua Sun, Jinlan Zhang. An in vivo microdialysis study of FLZ Penetration through the Blood-Brain Barrier in Normal and 6-Hydroxydopamine Induced Parkinson’s Disease Model Rats. BioMed Research international, 2014, 850493.

19.   Qian Liu, Jinfeng Hou, Xiaoguang Chen, Gengtao Liu, Dan Zhang, Hua Sun, Jinlan Zhang. P-Glycoprotein Mediated Efflux Limits the transport of the Novel Anti-Parkinson’s Disease Candidate Drug FLZ across the Physiological and PD Pathological in vitro BBB Models. PLOS ONE, 2014, 9, e102442.

20.   Zhixin Jia, Caisheng Wu, Hongtao Jin, Jinlan Zhang. Identification of the chemical components of Saussurea involucrate by high-resolution mass spectrometry and the mass spectral trees similarity filter technique. Rapid communications in mass spectrometry, 2014, 28, 2237-2251.

21.   Feng Qu, Sujun Zheng, Shuang Liu, Caisheng Wu, Zhongping Duan, Jinlan Zhang. Serum Sphingolipids reflect the Severity of Chronic HBV Infection and Predict the Mortality of HBV-Acute-on-Chronic Liver Failure. PLOS ONE, 2014, 9, e104988.

22.   Ying Jin, Cai-Sheng Wu, Jin-Lan Zhang, Ying-Fei LiA new strategy for the discovery of epimedium metabolites using high-performance liquid chromatography with high resolution mass spectrometryAnalytica Chimica Acta, 2013, 768, 111– 117

23.   Qiang Ren, Caisheng Wu, Jinlan Zhang, Use of on-line stop-flow heart-cutting two-dimensional high performance liquid chromatography for simultaneous determination of 12 major constituents in tartary buckwheat (Fagopyrum tataricum Gaertn) , Journal of Chromatography A, 2013, 1304, 257– 262

24.   Qiang Ren, Caisheng Wu, Yan Ren, Jinlan ZhangCharacterization and identification of the chemical constituents from tartary buckwheat (Fagopyrum tataricum Gaertn) by high performance liquid chromatography/photodiode array detector/linear ion trap FTICR hybrid mass spectrometryFood Chemistry, 2013, 136, 1377–1389

25.   Jinfeng Hou, Feng Qu, Caisheng Wu, Qiang Ren, Jinlan Zhang,Quantitative determination and pharmacokinetic study of the novel anti-Parkinson’s disease candidate drug FLZ in rat brain by high performance liquid chromatography–tandem mass spectrometryJournal of Pharmaceutical and Biomedical Analysis, 2012,66, 232– 239.

26.   Yan Ren Caisheng WuJinlan ZhangSimultaneous screening and determination of 18 illegal adulterants in herbal medicines and health foods for male sexual potency by ultra-fast liquid chromatographyelectrospray ionization tandem mass spectrometryJ. Sep. Sci., 2012, 35, 2847–2857

27.    Wu CS, Zhang JL, Zhou TH, Guo BL, Wang YL, Hou JF. Simutaneous determination of seven flavonoids in dog plasma by ultra-performance liquid chromatography-tandem mass spectrometry and its application to a bioequivalence study of bioactive components in Herba Epimedii and Er-Xian Decoction[J]. Journal of Pharmaceutical and Biomedical Analysis, 2011, 54, 186-191

28.   Chun-Yan Niu, and Jin-Lan Zhang,Quantitative analysis and chromatographic fingerprinting of the semen zizyphi spinosaeby ultra-high-performance liquid chromatography coupled with diode-array detectorJournal of separation science, 2011, 34, 2989-2996

29.    Yilin Wang, Chunguang Ding, Kehe Du, Yao Xiao, Caisheng Wu, Jinlan Zhang, Hailin Qin and Guanhua DuIdentification of active compounds and their metabolites by high-performance liquid chromatography/electrospray ionization Fourier transform ion cyclotron resonance mass spectrometry from Xiao-xu-ming decoction (XXMD)Rapid Commun. Mass Sp, 2009, 23, 2724–2732

30.    Caisheng Wu, Yuxin Sheng, Yinghao Zhang, Jinlan Zhang and Baolin GuoIdentification and characterization of active compounds and their metabolites by high-performance liquid chromatography/Fourier transform ion cyclotron resonance mass spectrometry after oral administration of a herbal extract of Epimedium koreanum Nakai to ratsRapid Commun. Mass Sp, 2008, 22, 2813–2824.

31.    W. Zhang, Y.X. Sheng, J.L. Zhang, Determination and pharmacokinetics of gastrodin and p-hydroxybenzylalcohol after oral administration of Gastrodia elata Bl. extract in rats by high-performance liquid chromatography–electrospray ionization mass spectrometric method. Phytomedicine, 2008, 15, 844-850.

 

获奖情况

11998年获中华人民共和国卫生部科学技术进步奖二等奖,获奖项目:藁本的化学研究,排名第六。

22008年获中华人民共和国教育部自然科学奖一等奖,获奖项目:中药复杂体系成分分析及体内过程研究,排名第六

32014年获中国药学会科学技术奖三等奖,获奖项目:临床常用药物中微量杂质检测和安全控制关键技术研究与应用,排名第四

42018年获得中国分析测试协会科学技术奖一等奖,获奖项目:中草药成分及其代谢分析新方法和应用,排名第一

 

 

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