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高钟镐

时间:2017/7/6 来源: 阅读:29393次


高钟镐

 

高钟镐,男,博士,19631月出生,朝鲜族,现任中国医学科学院北京协和医学院药物研究所研究员、博士研究生导师。

1994年留学韩国首尔国立大学(Seoul National University),师从韩国药学会会长金钟国教授攻读博士学位,1998年毕业获得药学博士,主要研究方向为生物物理药剂学;2001-2003年进入美国哈佛大学和东北大学进行博士后研究,师从美国药物控释学会会长Vladimir P Torchilin教授,主要从事药物控释和靶向制剂研究。19982月至20001月任职于韩国首尔国立大学,担任助理研究员;20001月至20011月就职于韩国忠北国立大学,担任研究员职务;20033月至20082月,任职于美国犹他大学,担任生物工程系和药学系助理教授。20082月,作为国际高端人才被中国医学科学院北京协和医学院药物研究所人才引进作为药剂学科带头人,担任研究员和博士生导师,主要从事纳米释药系统、肿瘤靶向制剂和核酸递送载体等研究工作。曾获中国医学科学院药物研究所精神文明建设先进个人荣誉称号。2008年回国后,作为博士生导师开始招收北京协和医学院历史上第一届药剂学专业博士研究生。已招收博士生6人、直博生2人和硕士生1人。研究生培养成绩显著,已毕业博士生5人,其中2名博士毕业生荣获北京市优秀毕业生称号。

主持承担多项课题研究,包括美国国家卫生院生物工程部癌症协会基金、美国犹他大学基金、国家自然科学基金、中央级公益性科研院所基本科研业务费专项基金、北京市自然科学基金重点项目、国家科技部重大新药创制专项基金、高等学校博士学科点专项科研基金等科研项目。发表论文80多篇,包括SCI论文60余篇,且多篇论文发表于著名期刊,包括Journal of the National Cancer InstituteNano LettersPNASBiomaterialsSmallJournal of Controlled ReleaseActa BiomaterialiaMolecular Pharmaceutics等。现兼任药学学报(中英文版)编委、国家药物价格评审专家、中国医药生物技术杂志编委,长期担任BiomaterialsJournal of Controlled ReleaseMolecular PharmaceuticsPharmaceutical ResearchInternational Journal of Pharmaceutics等国际期刊审稿人。 

 

联系方式

地址:北京市先农坛街1

邮编:100050

电话:010-63028096

E-mailzggao@imm.ac.cn

 

主要科研成果:

(一)论文发表 (#co-first author, *corresponding author)

1)    Wei Huang#, Liqing Chen#, Lin Kang#, Mingji Jin, Ping Sun, Xin Xin, Zhonggao Gao*, You Han Bae. Nanomedicine-based combination anticancer therapy between nucleic acids and small-molecular drugs. Advanced Drug Delivery Reviews, 2017, In press, http://dx.doi.org/10.1016/j.addr.2017.06.004. (IF11.764)

2)    Bo Fan, Lin Kang, Liqing Chen, Ping Sun, Mingji Jin, Qiming Wang, You Han Bae, Wei Huang*, Zhonggao Gao*. Systemic siRNA Delivery With a Dual pH-Responsive and Tumor-targeted Nanovector for Inhibiting Tumor Growth and Spontaneous Metastasis in Orthotopic Murine Model of Breast Carcinoma. Theranostics, 2017, 7(2):357-376. (IF8.712)

3)    Xiao-DanYan, Qi-Ming Wang, Cai Tie, Hong-Tao Jin, Yan-Xing Han, Jin-Lan Zhang, Xiao-MingYu, Qi Hou, Piao-Piao Zhang, Ai-Ping Wang, Pei-Cheng Zhang*, Zhong-Gao Gao*, Jian-Dong Jiang*. Polydatin protects the respiratory system from PM2.5 exposure. Scientific Reports, 2017, 7:40030. DOI: 10.1038/srep40030. (IF4.259)

4)    Ping Sun, Wei Huang*, Lin Kang, Mingji Jin, Bo Fan, Hongyan Jin, Qiming Wang, Zhonggao gao*. siRNA-loaded poly(histidine-arginine)6-modifed chitosan nanoparticle with enhanced cell-penetrating and endosomal escape capacities for suppressing breast tumor metastasis. International Journal of Nanomedicine, 2017, 12:3221–3234. (IF4.300)

5)    Lin Kang, Bo Fan, Ping Sun, Wei Huang, Mingji Jin, Qiming Wang, Zhonggao Gao*. An effective tumor-targeting strategy utilizing hypoxia-sensitive siRNA delivery system for improved anti-tumor outcome. Acta Biomaterialia, 2016, 44:341-354. (IF6.319)

6)    Ping Sun, Wei Huang, Mingji Jin, Qiming Wang, Bo Fan, Lin Kang, Zhonggao gao*. Chitosan-based nanoparticles for survivin targeted siRNA delivery in breast tumor therapy and preventing its metastasis. International Journal of Nanomedicine, 2016,11:4931-4945. (IF4.300)

7)    Liqing Chen, Wei Huang*, Zhonggao Gao*, Weishuo Fang, Mingji Jin. Lx2-32c-loaded polymeric micelles with small size for intravenous drug delivery and inhibitory effect on tumor growth and metastasis against clinically associated 4T1 murine breast cancer. International Journal of Nanomedicine, 2016, 11: 5457-5472. (IF4.300)

8)    Shan Liu#, Wei Huang#, Mingji Jin, Bo Fan, Guimin Xia, Zhonggao Gao*. Inhibition of murine breast cancer growth and metastasis by survivin-targeted siRNA using disulfide cross-linked linear PEI. European Journal of Pharmaceutical Sciences, 2016, 82:171–182. (IF3.756)

9)    Li-qing Chen#, Zhe-ming Zhang#, Wei Huang*, Zhong-gao Gao*, Wei-shuo Fang, Ming-ji Jin, Lian Yu. Inhibiting the proliferation, migration and invasion of triple negative breast cancer cells through anti-tumor human serum albumin nanoparticles loading Aziditaxel as a novel taxane derivative. Pharmazie, 2017, 72(3):152-160. (IF1.126)

10) Lin Kang, Zhonggao Gao*, Wei Huang, Mingji Jin, Qiming Wang. Nanocarrier-mediated co-delivery of chemotherapeutic drugs and gene agents for cancer treatment. Acta Pharmaceutica Sinica B, 2015, 5(3): 169-175.

11) Qiming Wang, Zhonggao Gao*, Shan Liu, Bo Fan, Lin Kang, Wei Huang, Mingji Jin. Hybrid polymeric micelles based on bioactive polypeptides as pH-responsive delivery systems against melanoma. Biomaterials, 2014, 35(25): 7008-7021. (IF8.557)

12) Shan Liu, Wei Huang, Mingji Jin, Qiming Wang, Ganlin Zhang, Xiaomin Wang, Shuai Shao, Zhonggao Gao*. Efficient gene delivery of alkylated low molecular weight polyethylenimine through gemini surfactant-like effect. International Journal of Nanomedicine, 2014, 9(1): 3567-3581. (IF4.383)

13) Feifei Yang#, Wei Huang#, Yunfei Li, Shan Liu, Mingji Jin, Yuli Wang, Lihua Jia, Zhonggao Gao*. Anti-tumor effects in mice induced by Survivin-targeted siRNA delivered through polysaccharide nanoparticles. Biomaterials, 2013, 34(22): 5689-5699. (IF8.312)

14) Yunfei Li, Mingji Jin, Shuai Shao, Wei Huang, Feifei Yang, Wei Chen, Shenghua Zhang, Guimin Xia, Zhonggao Gao*. Small-sized polymeric micelles incorporating docetaxel suppress distant metastases in the clinically-relevant 4T1 mouse breast cancer model. BMC Cancer, 2014, 14:329. (IF3.362)

15) Mingji Jin, Wei Chen, Wei Huang, Long Rong, Zhonggao Gao*. Preparation of pegylated lumbrokinase and an evaluation of its thrombolytic activity both in vitro and in vivo. Acta Pharmaceutica Sinica B, 2013, 3(2):123-129.

16) Yunfei Li, Feifei Yang, Wei Chen, Jiaoyang Liu, Wei Huang, Mingji Jin, and Zhonggao Gao*. A Novel Monomethoxy Polyethylene Glycol-Polylactic Acid Polymeric Micelles with Higher Loading Capacity for Docetaxel and Well-Reconstitution Characteristics and Its Anti-metastasis Study. Chem Pharm Bull, 2012, 60(9):1146-1154.

17) Wei Huang, Ming Lv, Zhong Gao Gao*. Synthesis of polyethylenimine grafted with copolymers of polyethylene glycol and polycaprolactone and its potential for siRNA delivery. Chinese Chemical Letters, 2011, 22(6):749-752.

18) Zhong Gao Gao, Li Tian, Jun Hu, In Suh Park, You Han Bae. Prevention of Metastasis in a 4T1 Murine Breast Cancer Model by Doxorubicin Carried by Folate Conjugated pH Sensitive Polymeric Micelles. Journal of Controlled Release, 2011, 152: 84-89.

19) Natalya Rapoport, Kweon-Ho Nam, Roohi Gupta, Zhonggao Gao, Praveena Mohan, Allison Payne, Nick Todd , Xin Liu , Taeho Kim, Jill Shea, Courtney Scaife, Dennis L. Parker, Eun-Kee Jeong, Anne M. Kennedy. Ultrasound-mediated tumor imaging and nanotherapy using drug loaded, block copolymer stabilized perfluorocarbon nanoemulsions. Journal of Controlled Release, 2011,153 (1):4-15.

20) D. Kim, Z.G. Gao, E.S. Lee, Y.H. Bae. In vivo evaluation of doxorubicin-loaded polymeric micelles targeting folate receptors and early endosomal pH in drug-resistant ovarian cancer. Molecular Pharmaceutics. 2009, 6(5):1353-1362.

21) Ge Jiang , Yingzhi Jiang, Yuanyuan Shen , Kweon-Ho Nam, Zhonggao Gao*.  DNA Loaded Nano particle Reduced Binding and Preferential Extravasation from Tumor Blood Vessel. International Journal of Pharmaceutics, 2009, 369(1-2):155-61.

22) Dongin Kim, Eun Seong Lee, Kyung Taek Oh, Zhong Gao Gao, and You Han Bae. Doxorubicin-oaded Polymeric Micelle Overcomes Multidrug Resistance of Cancer by Double-Targeting Folate Receptor and Early Endosomal pH. Small, 2008, 4 (11):2043-2050.

23) N. Rapoport, Z. Gao, A.M. Kenneday. Multifunctional nanoparticles for combining ultrasonic tumor imaging and targeted chemotherapy. Journal of the National Cancer Institute, 2007, 99(14): 1095-1106.

24) V.P. Torchilin, A.N. Lukyanov, Z. Gao, B. Papahajopoulos-Sternberg, Immunomicelles-targeted Pharmaceutical Carriers for Poorly Soluble Drugs. Proc. Natl. Acad. Sci.  2003, 100 (10), 6039-44.

25) Z.G. Gao, A.N. Lukyanov, A. Singhal, V.P. Torchilin. Diacyllipid-polymer micelles as nanocarriers for poorly soluble anticancer drugs. Nano Letters, 2002, 2(9) 979-982.

26) A.N. Lukyanov, Z.G. Gao, L. Mazzola, and V.P. Torchilin. Polyethylene glycol-diacyllipid micelles demonstrate increased accumulation in subcutaneous tumors in mice. Pharmaceutical Research. 2002, 19 (10) 1422-1427.

27) Eun Seong Lee, Zhonggao Gao, Dongin Kim, Kyeongsoon Park, Ick Chan Kwon and You Han Bae. Super pH-sensitive multifunctional polymeric micelle for tumor pH(e) specific TAT exposure and multidrug resistance. Journal of Controlled Release. 2008, 129(3):228-236.

28) Eun Seong Lee, Zhonggao Gao, You Han Bae. Recent progress in tumor pH targeting Nanotechnology. Journal of Controlled Release. 2008, 132(3):164-70.

29) Gao, Zhong-Gao, Jin, Zhe-Hu, Yin, Xue-Zhe, Tian, Li. Multifunctional Nanparticles for Targeting Cancer Therapy. J Nanosci Nanotechno. 2010, 10 (11):7743-774.

30) Dong-Han Han, Zhe-Hu Jin, Yan-Zhe Jin, Xue-zhe Yin,Yuan-Yuan Shen, and Zhong-Gao Gao. Thermal Reversible Microemulsion System for Poorly Water Soluble YH439 for Oral Delivery. Chemical & Pharmaceutical Bulletin. 2010, 58(1):11-15.

31) Z. Gao, H. D. Fain, and N. Rapoport. Combined Tumor Chemotherapy by Micellar-Encapsulated Drug and Ultrasound. Journal of Controlled Release. 2005,102 (1): 203-222.

32) Z. Gao, H. D. Fein, N.Y. Rapoport. Ultrasound-Triggered Targeting of Micellar-Encapsulated Drugs to Ovarian Carcinoma Tumors In Vivo. Molecular Pharmaceutics. 2004, 1(4): 317-330.

33) A.N. Lukyanov, Z.G. Gao, V.P. Torchilin. Micelles from polyethylene glycol/ phosphatidylethanolamine conjugates for tumor drug delivery. Journal of Controlled Release. 2003, 91 (1) 97-102.

34) E.Y. Kim, Z.G.. Gao, J.S. Park, H. Li, K. Han. rhEGF/HP-beta-CD complex in poloxamer gel for ophthalmic delivery. International Journal of Pharmaceutics. 2002, 233 159-67.

35) K. Han, K.D. Lee, Z.G. Gao and J.S. Park. Preparation and evaluation of Poly (L-lactic acid) microspheres containing rhEGF for chronic gastric ulcer healing. Journal of Controlled Release. 2001, 75 259-69.

36) C.K. Kim, Y.J. Chao, Z.G. Gao. Preparation and evaluation of biphenyl dimethyl dicarboxylat microemulsions for oral delivery. Journal of Controlled Release. 2001, 70:149-155.

37) C.K. Kim, S.W. Lee, H.G. Choi, M.K. Lee, Z.G. Gao, I.S. Kim and K.M. Park. Trials of in situ-gelling and mucoashesive acetaminophen liquid suppository in human subjects. International Journal of Pharmaceutics, 1998,174, 201-207.

38) Z.G. Gao, H.J. Shin, K.M Park, S.J. Lim, K.J. Hwang, and C.K. Kim. Physicochemical characterization and evaluation of a microemulsion system for oral delivery of Cyclosporin A. International Journal of Pharmaceutics. 1998, 161, 75-86.

39) N. Rapoport, K.H. Nam, Z. Gao, and A. Kennedy. Application of Ultrasound for Targeted Nanotherapy of Malignant Tumors. Acoustical Physics. 2009, 55:594-601.

40) Rapoport N, Nam KH, Gao Z, Cristensen DA, Kennedy AM. Acoustic properties of multifunctional nanomicrobubbles used in ultrasonography and ultrasound-mediated chemotherapy. J Acoust Soc Am. 123(5):3217

41) Zhonggao Gao, Anne M. Kennedy, Douglas A. Christensen, and Natalya Y. Rapoport. , Drug-Loaded Nano/Microbubbles for Combining Ultrasonography and Targeted Chemotherapy, Ultrasonic, 2008, 484260-270.

42) P.P. Kamaev, Z. Gao, D.A. Christensen N. Rapoport. Effect of Dox on the sensitivity of HCT116 human colon cancer cells to ultrasound. Am. J. Physic. 2007, 4(2): 97-104.

43) B. Howard, Z. Gao, N. Rapoport. Ultrasound-Enhanced Chemotherapy of Drug Resistant Breast Cancer Tumors by Micellar-Encapsulated Paclitaxel. Am. J. Drug Delivery. 2006, 4(4):97-104.

44) Z.G. GAO, D.H. LEE, D.I. KIM, Y.H.BAE. pH-Sensitive Micelle Targeting Acidic extracellular pH of Human Ovarian A2780 Tumor in Mice. J. Drug Targeting, 2005, 13(7): 391-397.

45) N.Y. Rapoport, D.A. Christensen, H. D. Fein, L. Barrows, Z. Gao. Ultrasound-triggered drug targeting to tumors in vitro and in vivo. 2004, Ultrasonics. 42: 943-50.

46) Z. Gao, AN. Lukyanov, AR. Chakilam, VP. Torchilin. PEG-PE/phosphatidylcholine mixed immunomicelles specifically deliver encapsulated taxol to tumor cells of different origin and promote their efficient killing. J. Drug Targeting. 2003, 11 (2):87-92.

47) V.P. Torchilin, A.N. Lukyanov, Z.G. Gao, Polymer-lipid micelles as non-targeted and targeted pharmaceutical carriers. Polymer preprints. 2002, 43 (2): 677.

48) Z.G. Gao, M.K. Lee, U. Oh, Y.G. Suh, C.K. Kim. Determination of capsazepine in rat plasma by high performance liquid chromatography. J. Liq. Chorm. & Rel. Technol., 2000, 23(12):1865-1872.

49) Z.G. Gao, K.H. Oh, and C.K. Kim. Preparation and characterization of sustained-release microespheres of chlorpromazine. J. of Microencapsulation., 1998, 15(1), 75-81.

50) C.K. Kim, E.J. Lee, M.K. Lee, J.K. Park, H.J. Shin, S.W. Lee, S.J. Lim, Z.G. Gao and I.S. Kim. Bioequivalence of Cyclosporin A hard capsules. J. of Applied of Pharmacology, 1998, 6: 296-302.

51) C.K. Kim, S.W. Lee, Z.G. Gao, M.K. Lee, I.S. Kim and H.G. Choi. Bioequuivalence of two nilvadipine tablets. The J. of Applied of Pharmacology. 1998, 6: 289-295.

52) C.K. Kim, S.W. Lee, H.G. Choi, Z.G. Gao, M.K.Lee and I.S. Kim. Bioequuivalence of two clarithromycin tablets. The J. of Applied of Pharmacology. 1998, 6:219-224.

53) C.K. Kim, H.G. Choi, S.W. Lee, Z.G. Gao, M.K. Lee, S.J. Lim, Y.J. Park and I.S. Kim. Preparation and bioequivalence test of acetaminophen liquid suppository. The Journal of Applied of Pharmacology. 1998, 6: 213-218.

54) K.M. Park, Z.G. Gao, and C.K. Kim. Assay of flurbiprofen in rat plasma using HPLC with fluorescence detection. J. Liq.Chrom. & Rel. Technol., 1997, 20: 1849-1855.

 

(二)参编论著:

1. V.P. Torchilin, A.N. Lukyanov, Z. Gao, J. Wang, and T.S. Levchenko, 2004, Chapter 9: “Polymeric Micelles as Targetable Pharmaceutical Carriers”. Edited by sonke Svenson on Carrier based drug delivery.

2. Zhonggao Gao, Mingji Jin2011, Chapter 14, Page 1-16, “Multifuntinonal Nanoparticle for Tumor Targeting Thearpy”, Edited by Balaji Sitharaman on Nanobiomaterials Handbook.

3. Zhonggao Gao, 2012 “Thermal Revisable Microemulsion for Poorly Water-Soluble Drugs Oral Delivery” Edited by Reza Najjar on Microemulsion. Page 135-150.

 

(三)专利申请:

1) 高钟镐, 黄伟, 孙平. 一种壳聚糖衍生物的制备及应用. 请号:201611207106.4

2) 高钟镐, 黄伟, 王晓良, 王琰, 黄海洪, 彭英, 陈丽青. 一种治疗阿尔兹海默病的缓释制剂及其制备方法. 申请号:201510275408.4

3) 高钟镐, 黄伟, 杨飞飞, 柳珊, 金明姬. 寡聚精氨酸共价修饰的壳聚糖、制备方法、筛选及应用. 申请号:201410320869.4

4) 高钟镐, 柳珊, 黄伟, 杨飞飞, 金明姬. 还原敏感性聚乙烯亚胺衍生物, 其制备方法及应用. 申请号:201410112675.5

5) 高钟镐, 李云飞, 陈卫, 杨飞飞, 黄伟, 金明姬. 甲基聚乙二醇2000-b-D,L-乳酸1000-1500 嵌段共聚物载多烯紫杉醇纳米胶束制剂. 申请号:201410053888.5

6) 高钟镐, 陈卫, 金明姬, 方唯硕. 一种紫杉烷类长循环纳米粒及其制备方法. 申请号:201410053890.2

7) 高钟镐, 黄伟, 柳珊, 杨飞飞, 金明姬. 脂肪烃基接枝的低分子量聚乙烯亚胺,制备方法及应用. 申请号:201310244851.6

8) 高钟镐, 王启明. 递送药物的pH敏感型聚合物胶束. 申请号:201310465091.1

9) Natalya Rapoport, Zhonggao Gao, Echogenic Microbubbbles for Ultrasound-enhanced micelle-encapsulated drug delivery.国际专利号:PCT/US2006/020347

10) Viradimir P .Torchilin, Zhonggao Gao, Micelle delivery system loaded with a pharmaceutical agent.国际专利号:PCT/US2003 /012042

11) Ken Han, Zhonggao, Gao, Dry liposome compositions containing water-soluble, peptide-based drugs, and preparation method thereof. 韩国专利号: 10-2000-0063457

12) Fisher Darrell, Bae You Han, Zhonggao Gao. Brachytherapy Seed with Fast Dissolving Matrix for Optimal Delivery of Radionuclides to Cancer Tissue. 国际专利PCT/US2009/055738

13) You Han Bae, Eun Seong Lee, Dongin Kim, Zhonggao Gao. PH-Sensitive polymeric micelles for drug delivery.美国专利号:20100009926

14) Natalia Rapoport, Zhonggao Gao, Echogenic, microbubbles and microemulsions for ultrasound-enhanced nanoparticle-mediated delivery of agents.美国专利号:20090117177.

 

 

 

 

 

 

 

 

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