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黄伟

时间:2020/4/7 来源: 阅读:17347次


黄伟

 

 

黄伟,男,博士,研究员,博士研究生导师。

      主要从事药剂学研究工作,研究方向为纳米释药系统、基因递送载体和创新制剂研究。1999年毕业于沈阳药科大学药物分析专业,获学士学位;2002年毕业于军事医学科学院药剂学专业,获硕士学位;2008年毕业于香港中文大学化学病理学专业,获博士学位(PhD);曾任香港中文大学医学院化学病理学系研究助理。作为中央第七批援疆干部,于20139月至20148月间支援新疆维吾尔自治区药物研究所建设与发展,任该所药剂室副主任。现任北京协和医学院药物研究所药物制剂研究室研究员,在基因递送载体和肿瘤靶向释药系统等研究方面具有坚实基础和丰富经验。已招收硕士研究生8人,培养毕业3人,其中1名毕业生获得国家奖学金并荣获“北京市优秀毕业生”称号。协助培养毕业博士研究生7人和硕士研究生5人。

      作为负责人,主持课题研究10多项,主要包括北京市自然科学基金、协和青年科研基金、美国中华医学基金会(CMB)基金项目等。作为主要参加人,参加课题研究20多项,主要包括“重大新药创制”国家科技重大专项基金、国家自然科学基金等项目。在国内进行了基因递送载体的开拓性研究,率先研制壳聚糖纳米粒基因递送系统。在基因递送载体、纳米释药系统和创新制剂等方面取得重要研究成果,申请发明专利15,发表论文50多篇,其中SCI论文最高影响因子13.66。曾获得2010年度中国医学科学院药物研究所“梁周黄于刘青年科技奖”三等奖、2012年《药学学报》第六届优秀研究论文奖、2013年第十一届全国医药卫生青年科技论坛三等奖。担任中国实验动物学会屏障医学专业委员会委员、《Chinese Chemical Letters》青年编委。 20148月,被中国共产党新疆维吾尔自治区委员会授予“第七批中央和国家机关、中央企业优秀援疆干部人才”称号,并荣获个人二等功。

联系方式:

E-mailhuangwei@imm.ac.cn

Tel: 010-63026505

教育背景:

20049月-20082月,香港中文大学,化学病理学专业,博士(PhD)。

19998月-20026月,军事医学科学院,药剂学专业,硕士。

19959月-19997月,沈阳药科大学,药物分析专业,学士。

工作经历:

20189月-至今,中国医学科学院药物研究所药物制剂研究室,研究员。

20129月-20188月,中国医学科学院药物研究所药物制剂研究室,副研究员。

20139月-20148月,为中组部第七批援疆干部,任新疆药物所药剂室副主任。

20089月-20128月,中国医学科学院药物研究所药物制剂研究室,助理研究员。

专业研究领域:

纳米释药系统

肿瘤靶向制剂

基因递送载体

近年代表性论文 (#co-first author, *corresponding author)

1)    Wei Huang#, Liqing Chen#, Lin Kang#, Mingji Jin, Ping Sun, Xin Xin, Zhonggao Gao*, You Han Bae. Nanomedicine-based combination anticancer therapy between nucleic acids and small-molecular drugs. Advanced Drug Delivery Reviews, 2017, 115:82-97. (IF: 13.66)

2)    Bo Fan, Lin Kang, Liqing Chen, Ping Sun, Mingji Jin, Qiming Wang, You Han Bae, Wei Huang*, Zhonggao Gao*. Systemic siRNA delivery with a dual pH-responsive and tumor-targeted nanovector for inhibiting tumor growth and spontaneous metastasis in orthotopic murine model of breast carcinoma. Theranostics, 2017, 7(2):357-376. (IF: 8.537)

3)    Feifei Yang#, Wei Huang# , Yunfei Li, Shan Liu, Mingji Jin, Yuli Wang, Lihua Jia, Zhonggao Gao*. Anti-tumor effects in mice induced by survivin-targeted siRNA delivered through polysaccharide nanoparticles. Biomaterials, 2013, 34(22):5689-5699. (IF: 8.312)

4)    Xiao-yang Chu#, Wei Huang#, Yu-li Wang, Ling-wei Meng, Li-qing Chen, Ming-ji Jin, Lu Chen, Chun-hong Gao, Cheng Ge, Zhong-gao Gao*, Chun-sheng Gao*. Improving anti-tumor outcomes for palliative intratumoral injection therapy through lecithin-chitosan nanoparticles loading paclitaxel-cholesterol complex. International Journal of Nanomedicine, 2019, 14:689-705. (IF: 4.471)

5)    Lingwei Meng, Xiaoyang Chu, Haoyue Xing, Xuan Liu, Xin Xin, Liqing Chen, Mingji Jin,Youyan Guan*, Wei Huang*, Zhonggao Gao*. Improving glioblastoma therapeutic outcomes via doxorubicin-loaded nanomicelles modified with borneol. 2019, International Journal of Pharmaceutics, 567: 118485. (IF: 4.213)

6)    Mingji Jin, Guangming Jin, Lin Kang, Liqing Chen, Zhonggao Gao*, Wei Huang*. Smart polymeric nanoparticles with pH-responsive and PEG-detachable properties for co-delivering paclitaxel and survivin siRNA to enhance antitumor outcomes. International Journal of Nanomedicine, 2018, 13:2405-2426. (IF: 4.471)

7)    Ping Sun, Wei Huang*, Lin Kang, Mingji Jin, Bo Fan, Hongyan Jin, Qiming Wang, Zhonggao gao*. siRNA-loaded poly(histidine-arginine)6-modifed chitosan nanoparticle with enhanced cell-penetrating and endosomal escape capacities for suppressing breast tumor metastasis. International Journal of Nanomedicine, 2017, 12:3221-3234. (IF: 4.37)

8)    Liqing Chen, Wei Huang*, Zhonggao Gao*, Weishuo Fang, Mingji Jin. Lx2-32c-loaded polymeric micelles with small size for intravenous drug delivery and their inhibitory effect on tumor growth and metastasis in clinically associated 4T1 murine breast cancer. International Journal of Nanomedicine, 2016, 11:5457-5472. (IF: 4.3)

9)    Shan Liu#, Wei Huang#, Mingji Jin, Bo Fan, Guimin Xia, Zhonggao Gao*. Inhibition of murine breast cancer growth and metastasis by survivin-targeted siRNA using disulfide cross-linked linear PEI. European Journal of Pharmaceutical Sciences, 2016, 82:171-182. (IF: 3.756)

10) Cheng Zeng, Wen Jiang, Meie Tan, Xiaoyi Yang, Chenghui He, Wei Huang*, Jianguo Xing*. Optimization of the process variables of tilianin-loaded composite phospholipid liposomes based on response surface-central composite design and pharmacokinetic study. European Journal of Pharmaceutical Sciences, 2016, 85:123-131. (IF: 3.756)

11) Li-qing Chen#, Zhe-ming Zhang#, Wei Huang*, Zhong-gao Gao*, Wei-shuo Fang, Ming-ji Jin, Lian Yu. Inhibiting the proliferation, migration and invasion of triple negative breast cancer cells through anti-tumor human serum albumin nanoparticles loading aziditaxel as a novel taxane derivative. Pharmazie, 2017, 72(3):152-160. (IF: 1.016)

12) Mei-e Tan, Cheng-hui He, Wen Jiang, Cheng Zeng, Ning Yu, Wei Huang*, Zhong-gao Gao, Jian-guo Xing*. Development of solid lipid nanoparticles containing total flavonoid extract from Dracocephalum moldavica L. and their therapeutic effect against myocardial ischemia-reperfusion injury in rats. International Journal of Nanomedicine, 2017, 12:3253-3265. (IF: 4.37)

13) Yuli Wang#, Ning Yu#, Rui Guo#, Meiyan Yang, Li Shan, Wei Huang*,Wei Gong, Shuai Shao, Xiaoping Chen, Chunsheng Gao*. Enhancing in vivo bioavailability in beagle bogs of GLM-7 as a novel anti-leukemia drug through a self-emulsifying drug delivery system for oral delivery. Current Drug Delivery, 2016, 13:131-142. (IF: 2.516)

14) Yuli Wang, Jiahui Yang, Yong Qian, Meiyan Yang, Yan Qiu, Wei Huang*, Li Shan, Chunsheng Gao*. Novel ethylcellulose-coated pellets for controlled release of metoprolol succinate without lag phase: characterization, optimization and in vivo evaluation. Drug Development and Industrial Pharmacy, 2015, 41(7):1120-1129. (IF: 2.429)

15) Ning Yu, ChenHui He, Gulistan Awuti, Cheng Zeng, JianGuo Xing*, Wei Huang*. Simultaneous Determination of Six Active Compounds in Yixin Badiranjibuya Granules, a Traditional Chinese Medicine, by RP-HPLC-UV Method. Journal of Analytical Methods in Chemistry, 2015:974039. (IF: 1.369)

16) Yedan Wu, Wei Huang, Liqing Chen, Mingji Jin, Zhonggao Gao*, Changshan An*, Haixiang Lin. Anti-tumor outcome evaluation against non-small cell lung cancer in vitro and in vivo using PolyI:C as nucleic acid therapeutic agent. American Journal of Translational Research, 2019, 11(4): 1919-1937. (IF: 3.061)

17) Mengjiao Wang, Liqing Chen, Wei Huang, Mingji Jin, Qiming Wang, Zhonggao Gao*, Zhehu Jin*. Improving the anti-keloid outcomes through liposomes loading paclitaxel–cholesterol complexes. International Journal of Nanomedicine, 2019,14:1385-1400. (IF: 4.37)

18) Wenyu Jin, Wei Huang, Liqing Chen, Mingji Jin, Qiming Wang, Zhonggao Gao*, Zhehu Jin*. Topical application of JAK1/JAK2 inhibitor momelotinib exhibits significant anti-Inflammatory responses in DNCB-induced atopic dermatitis model mice. International Journal of Molecular Sciences, 2018, 19(12), 3973. (IF: 3.687)

19) Qiming Wang, Zhonggao Gao*, Shan Liu, Bo Fan, Lin Kang, Wei Huang, Mingji Jin. Hybrid polymeric micelles based on bioactive polypeptides as pH-responsive delivery systems against melanoma. Biomaterials, 2014, 35(25):7008-7021. (IF: 8.557)

20) Lin Kang, Bo Fan, Ping Sun, Wei Huang, Mingji Jin, Qiming Wang, Zhonggao Gao*. An effective tumor-targeting strategy utilizing hypoxia-sensitive siRNA delivery system for improved anti-tumor outcome. Acta Biomaterialia, 2016, 44:341-354. (IF: 6.319)

21) Holly Y. Chen#, Suk Ling Ma#, Wei Huang, Lindan Ji, Vincent H. K. Leung, Honglin Jiang, Xiaoqiang Yao, Nelson L. S. Tang*. The mechanism of transactivation regulation due to polymorphic short tandem repeats (STRs) using IGF1 promoter as a model. Scientific Reports, 2016, 6:38225. (IF: 4.259)

22) Ping Sun, Wei Huang, Mingji Jin, Qiming Wang, Bo Fan, Lin Kang, Zhonggao Gao*. Chitosan-based nanoparticles for survivin targeted siRNA delivery in breast tumor therapy and preventing its metastasis. International Journal of Nanomedicine, 2016,11:4931-4945. (IF: 4.3)

23) Mingji Jin, Guangming Jin, Wei Huang, Zhonggao gao*. PEGylation of Lumbrokinase improves pharmacokinetic profile and enhances anti-thrombotic effect in a rat carotid artery thrombosis model. Molecular Medicine Reports, 2017, 16(4):4909-4914. (IF: 1.922)

24) Shan Liu, Wei Huang, Mingji Jin, Qiming Wang, Ganlin Zhang, Xiaomin Wang, Shuai Shao, Zhonggao Gao*. High gene delivery efficiency of alkylated low-molecular-weight polyethylenimine through gemini surfactant-like effect. International Journal of Nanomedicine, 2014, 9:3567-3581. (IF: 4.383)

25) Yunfei Li, Mingji Jin, Shuai Shao, Wei Huang, Feifei Yang, Wei Chen, Shenghua Zhang, Guimin Xia, Zhonggao Gao*. Small-sized polymeric micelles incorporating docetaxel suppress distant metastases in the clinically-relevant 4T1 mouse breast cancer model. BMC Cancer, 2014, 14:329. (IF: 3.362)

26) Holly Y. Chen, Wei Huang, Vincent H. K. Leung, Simon L. M. Fung, Suk Ling Ma, Hongling Jiang, Nelson L. S. Tang*. Functional interaction between SNPs and microsatellite in the transcriptional regulation of insulin-like growth factor 1. Human Mutation, 2013, 34(9):1289-1297. (IF: 5.05)

27) Yunfei Li, Feifei Yang, Wei Chen, Jiaoyang Liu, Wei Huang, Mingji Jin, and Zhonggao Gao*. A novel monomethoxy polyethylene glycol-polylactic acid polymeric micelles with higher loading capacity for docetaxel and well-reconstitution characteristics and its anti-metastasis study. Chemical & Pharmaceutical Bulletin, 2012, 60(9):1146-1154. (IF: 1.564)

28) Wei Huang, Ming Lv, Zhong-gao Gao, Ming-ji Jin, Yuan-ji Xu, Xiao-dan Yu, Zhe-hu Jin, Xue-zhe Yin. Preparation and characterization of polymeric nanoparticles for siRNA delivery to down-regulate the expressions of exogenous and endogenous target genes. Pharmazie, 2012, 67(8):676-680. (IF: 0.962)

29) Suk Ling Ma, Wei Huang, Nelson L.S. Tang*, Linda C.W. Lam. MxA polymorphisms are associated with risk and age-at-onset in Alzheimer disease and accelerated cognitive decline in Chinese elders. Rejuvenation Research, 2012, 15(5):516-522. (IF: 2.919)

30) Wei Huang, Ming Lv, Zhong Gao Gao*. Synthesis of polyethylenimine grafted with copolymers of polyethylene glycol and polycaprolactone and its potential for siRNA delivery. Chinese Chemical Letters, 2011, 22(6):749-752.

31) Lin Kang, Zhonggao Gao*, Wei Huang, Mingji Jin, Qiming Wang. Nanocarrier-mediated co-delivery of chemotherapeutic drugs and gene agents for cancer treatment. Acta Pharmaceutica Sinica B, 2015, 5(3):169-175.

32) Mingji Jin, Wei Chen, Wei Huang, Long Rong, Zhonggao gao*. Preparation of pegylated lumbrokinase and an evaluation of its thrombolytic activity both in vitro and in vivo. Acta Pharmaceutica Sinica B, 2013, 3(2):123-129.

 

 

 

 

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