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张天泰

时间:2019/7/16 来源: 阅读:23404次


张天泰

 

张天泰, 博士,研究员,博士生导师

联系电话:010-63035779, 邮箱:ttzhang@imm.ac.cn

 

教育背景

2000.9 – 2003.6,中国药科大学药学院,博士

1995.9 – 1998.6,兰州大学医学院,医学硕士

1988.9 – 1993.6,兰州大学公共卫生学院,医学学士

 

工作经历

2006.4 - 至今,中国医学科学院药物研究所,研究员

2003.9 - 2006.3,中国医学科学院药物研究所,博士后

1998.7 - 2003.8,兰州大学第一医院,副主任医师

1993.7 - 1995.8,甘肃省疾病预防与控制中心,住院医师

 

专业研究方向领域

研究领域为抗炎免疫药理学及新药发现,主要从事炎症相关的自身免疫性疾病的发病机制及免疫调控研究,利用生物分子事件寻找新的药物作用靶点和新药研究。

1. 炎症相关自身免疫性疾病的细胞和分子机制研究及新的药物作用靶点的发现;

2. 基于非受体酪氨酸激酶(JAK)的小分子先导物发现;

3. 活性天然产物的药理学评价及新药发现。

 

近年发表论文

1.     Hu M†, Xu CB†, Yang C, Zuo HL, Chen CJ, Zhang D, Shi GN, Wang WJ, Shi JG, Zhang TT*. Discovery and evaluation of ZT55, a novel highly-selective tyrosine kinase inhibitor of JAK2V617F against myeloproliferative neoplasms. J Exp Clin Cancer Res, Feb 2019, 38(2): 49. doi:  10.1186/s13.46-019-1062-x.

2.     Wang DM†, Hu M†, Li XP, Zhang D, Chen CJ, Fu JM, Shao S, Shi GN, Zhou Y, Wu S*, Zhang TT*. Design, synthesis, and evaluation of novel isoflavone derivatives as multifunctional agents for the treatment of Alzheimer‘s disease. Eur J Med Chem, Apr 2019, 168: 207-220. doi: 10.1016/j.ejmech.2019.02.053.

3.     Yu RN, Chen CJ, Shu L, Yin Y, Wang ZJ, Zhang TT*, Zhang DY*. Structure-based design and synthesis of pyrimidine-4,6-diamine derivatives as Janus kinase 3 inhibitors. Bioorgan & Med Chem, Apr 2019, 27(8):1646-1657, doi: 10.1016/j.bmc.2019.03.009.

4.     Yin Y, Chen CJ, Yu RN, Shu L, Zhang TT*, Zhang DY*. Discovery of novel selective Janus kinase 2 (JAK2) inhibitors bearing a 1H-pyrazolo[3,4-d]pyrimidin-4-amino scaffold. Bioorgan & Med Chem, Apr 2019, 27(8):1562-1576, doi: 10.1016/j.bmc.2019.02.054.

5.     Li JZ†, Ma XW†, Wang Y, Chen CJ, Hu M, Wang LL, Fu JM, Shi GN, Zhang DM, Zhang TT*. Methyl salicylate lactoside protects neurons ameliorating congnitive disorder through inhibiting neuroinflammatory response. Front. Aging Neurosci. 2018, 10: 85. doi: 10.3389/fnagi.2018.00085.

6.     Guo QL†, Xia H†, Shi GN, Zhang TT*, and Shi JG*. Aconicarmisulfonine A, a Sulfonated C20-Diterpenoid Alkaloid Inner Salt with Skeleton and Analgesic Activity from an Aqueous Extract of the Lateral Roots of Aconitum carmichaelii. Org lett, 2018, 20:816-819. doi: 10.1021/acs.orglett.7b03956.

7.     Guo QL†, Xia H†,  Meng XH,  Shi GN,  Xu CB,  Zhu CG,  Zhang TT*,  Shi JG*. C19-Diterpenoid alkaloid arabinosides from an aqueous extract of the lateral root of Aconitum carmichaelii and their analgesic activities. Acta Pharmaceut Sin B, May 2018, 8(3): 409-419. doi: 10.1016/j.apsb.2018.03.009.

8.     Yin Y, Chen C, Yu RN, Wang ZJ, Zhang TT*, Zhang DY*. Structure-Based Design and Synthesis of 1H-pyrazolo[3,4-d]pyrimidin-4-amino Derivatives as Janus Kinase 3 Inhibitors. Bioorgan & Med Chem, Sep 2018, 26(17):4774-4786, doi: 10.1016/j.bmc.2018.04.005.

9.     Li YJ, Zhou SB, Li JZ, Sun YH, Hamlati Hasimu, Liu R*, Zhang TT*. Quersetin protects human brain microvascular endothelial cells from fibrillar β-amyloid1-40-induced toxicity. Acta Pharmaceut Sin B, 2015, 5(1):47-54. doi: 10.1016/j.apsb.2014.12.003.

10.  Xin WY, Huang C, Zhang X, Xin S, Zhou YM, Ma XW, Zhang D, Li YJ, Zhou SB, Zhang DM, Zhang TT*, Du GH*. Methyl Salicylate Lactoside Inhibits Inflammatory Response and Joint Destruction on Fibroblast-like Synoviocytes and Collagen-Induced Arthritis Mice. Br J Pharmacol, 2014, 171(8):3526-38. doi:10.1111/bph.12715.

 

 

 

 

 

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