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苑玉和

时间:2014/3/12 来源: 阅读:10484次


苑玉和

 

苑玉和,女,副研究员,硕士生导师。

电话:010-63165182e-mail: yuanyuhe@imm.ac.cn

主要研究方向:抗帕金森病创新药物研制及作用机制的研究。具体研究内容:利用分子生物学技术,在分子、细胞和动物水平构建帕金森病研究模型及平台,在此基础上研究帕金森病发病机制及创新药物。近五年来负责课题共8项,其中国家级项目4项,北京市重点项目1项。近5年发表SCI收录文章30余篇,申请专利4项,部分成果如下:

发表文章

第一作者和通讯作者

1.   Yang Heng, Qiu-Shuang Zhang, Zheng Mu, Jin-Feng Hu, Yu-He Yuan*, Nai-Hong Chen* Ginsenoside Rg1 attenuates motor impairment and neuroinflammation in the MPTP-probenecid-induced parkinsonism mouse model by targeting α-synuclein abnormalities in the substantia nigra, Toxicol Lett, 2016; 243:7-21

2.   Yuan YH, Yan WF, Sun JD, Huang JY, Mu Z, Chen NH*.The molecular mechanism of rotenone-induced α-synuclein aggregation: Emphasizing the role of the calcium/GSK3β pathway. Toxicol Lett, 2015; 233: 163-171.

3.   Yuan YH, Sun JD, Wu MM, Hu JF, Peng SY, Chen NH*.Rotenone could activate microglia through NFκB associated pathway. Neurochem Res. 2013;38:1553-60

4.   Yan WF, Shao QH, Zhang DM, Yuan YH*, Chen NH*. The molecular mechanism of polygalasaponin F-mediated decreases in TNF α: emphasizing the role of the TLR4-PI3K/AKT-NF-κB pathway. J Asian Nat Prod Res, 2015; 17: 662-670.

5.   Wu MM, Yuan YH, Chen J, Li CJ, Zhang DM, Chen NH*. Polygalasaponin F against rotenone-induced apoptosis in PC12 cells via mitochondria protection pathway. J Asian Nat Prod Res 2014; 16:59-69. (共同第一)

6.   Wei W, Yuan YH, Gao YN, Yan WF, Li CJ, Zhang DM, Chen NH*. Polygalasaponin F inhibits secretion of inflammatory cytokines via NF-kappaB pathway regulation. J Asian Nat Prod Res 2014; 16:865-875.(共同第一)

7.   Yuan Y, Sun J, Zhao M, Hu J, Wang X, Du G, Chen NH*. Overexpression of alpha-synuclein down-regulates BDNF expression. Cell Mol Neurobiol. 2010;30:939-46.

8.   闫文芬, 衡洋,邵千航,陈乃宏,苑玉和*. 建立以α-突触核蛋白损伤为靶点的细胞筛选模型. 中国药理学通报, 2015; 31: 586 -590.

9.   闫文芬, 陈乃宏,苑玉和*.α-突触核蛋白与Cu2+ 相互作用的研究进展.中国药理学通报, 2015; 31: 7-10.

10.苑玉和,吴苗苗,刘岩,胡金凤,王宏旭,陈乃宏*,建立NF-kB核转位的转基因细胞模型,药理学通报,2012;28: 726-728

署名文章

1.      Yan JQ, Yuan YH, Gao YN, Huang JY, Ma KL, Gao Y, Zhang WQ, Guo XF, Chen NH*.Overexpression of human E46K mutant α-synuclein impairs macroautophagy via inactivation of JNK1-Bcl-2 pathway.Mol Neurobiol. 2014;50:685-701

2.      Ma KL, Song LK, Yuan YH, Zhang Y, Han N, Gao K, Chen NH*. The nuclear accumulation of alpha-synuclein is mediated by importin alpha and promotes neurotoxicity by accelerating the cell cycle.Neuropharmacology. 2014;82:132-42

3.      Ma KL, Song LK, Yuan YH, Zhang Y, Yang JL, Zhu P, Chen NH*.α-Synuclein is prone to interaction with the GC-box-like sequence in vitro. Cell Mol Neurobiol. 2014;34:603-9

4.      Song XY, Hu JF, Sun MN, Li ZP, Zhu ZX, Song LK, Yuan YH, Liu G, Chen NH* IMM-H004, a novel coumarin derivative compound, attenuates the production of inflammatory mediatory mediators in lipopolysaccharide-activated BV2 microglia.Brain Res Bull. 2014;106:30-8

5.      Song LK, Ma KL, Yuan YH, Mu Z, Song XY, Niu F, Han N, Chen NH*. Targeted Overexpression of α-Synuclein by rAAV2/1 Vectors Induces Progressive Nigrostriatal Degeneration and Increases Vulnerability to MPTP in Mouse. PLoS One 2015; 10: e0131281

6.      Liu Y, Sun JD, Song LK, Li J, Chu SF, Yuan YH, Chen NH*. Environment-contact administration of rotenone: A new rodent model of Parkinson’s disease. Behav Brain Res, 2015; 294: 149-161.

7.      Song XY, Hu JF, Chu SF, Zhang Z, Xu S, Yuan YH, Han N, Liu Y, Niu F, He X, Chen NH*.Ginsenoside Rg1 attenuates okadaic acid induced spatial memory impairment by the GSK3β/tau signaling pathway and the Aβ formation prevention in rats.,Eur J Pharmacol. 2013; 710:29-38.

8.      Ma KL, Song LK, Long WA, Yuan YH, Zhang Y, Song XY, Niu F, Han N, Chen NH*.Deletion in exon 5 of the SNCA gene and exposure to rotenone leads to oligomerization of α-synuclein and toxicity to PC12 cells. Brain Res Bull. 2013;90:127-31

9.      Sun JD, Liu Y, Yuan YH, Li J, Chen NH*. Gap junction dysfunction in the prefrontal cortex induces depressive-like behaviors in rats.Neuropsychopharmacology. 2012;37:1305-20

10.   Ma KL, Yuan YH, Song LK, Han N, Chen NH*.Over-expression of α-synuclein 98 triggers intracellular oxidative stress and enhances susceptibility to rotenone. Neurosci Lett. 2011;491:148-52.

负责在研项目

1.     国家自然科学基金面上项目:基于Nurr1介导的NF-κB信号通路研究瓜子金皂苷己的抗炎机制(81373997),2014/01-2017/12

2.     国家自然基金面上项目:人参皂苷Rg1通过α-突触核蛋白介导的炎症通路干预帕金森病的机制研究81573640),2016/01-2019/12

3.     北京市自然基金重点项目:以帕金森病的朊蛋白样聚集为靶点筛选新结构化合物和创新药物(7161011), 2016/01-2019/12

 

 

 

 

 

 

 

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