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张丹

时间:2012/10/24 来源: 阅读:12523次


张丹
 
张丹,博士,副研究员,硕士生导师。1978年出生。
 
联系方式:
电话:010-63165178
 
 
教育与研究工作简历:
1996.82001.7北京大学医学部药理系,获得理学学士学位
2001.82006.7中国医学科学院药物研究所药理系,获得博士学位
2006.82010.8 美国NIEHS, NIH,博士后
2010.8-至今中国医学科学院药物研究所,副研究员
 
专业研究领域:
主要研究方向为小胶质细胞和星形胶质细胞所介导的神经炎症在多种疾病发病以及治疗中的作用。同时从事调节炎症药物以及神经退行性疾病防治药物的筛选、评价以及机理研究。
目前承担国家自然科学基金和药物所基本科研业务费青年基金创新人才培养专项各一项,重大新药创制科技重大专项基金一项,天然药物活性物质与功能国家重点实验室课题一项。获得了2011年度“北京市科技新星”项目的资助以及2011年度“协和新星”项目的资助。2011年获得中国药学会-赛诺菲安万特青年生物药物奖。目前担任中国药理学会生化与分子药理专业委员会以及国家新药开发工程技术研究中心工程技术委员会委员。
 
过去5年发表文章:
1. Hu X, Zhou H, Zhang D, Yang S, Qian L, Wu HM, Chen PS, Wilson B, Gao HM, Lu RB, Hong JS. Clozapine Protects Dopaminergic Neurons from Inflammation-Induced Damage by Inhibiting Microglial Overactivation. J Neuroimmune Pharmacol. 2011 Aug 26. [Epub ahead of print]
2. Ye X, Tai WJ, Zhang D*.The early events of Alzheimers disease pathology: from mitochondrial dysfunction to BDNF axonal transport deficits. Neurobiology of Aging. 2011 Dec 31.
3. Bao XQ, Zhang D*. FLZ protects dopaminergic neuron through activating Akt/mTOR pathway and inhibiting RTP801 expression in Parkinsons disease models. Neuroscience. 2012 Jan 27;202:396-404.
4. Kong XC, Zhang D, Qian C, Liu GT, Bao XQ. FLZ, a novel HSP27 and HSP70 inducer, protects SH-SY5Y cells from apoptosis caused by MPP(+).Brain Res. 2011 Apr 6;1383:99-107.
5. Feng J*, Zhang D*, Chen B. Endothelial mechanisms of endothelial dysfunction in patients with obstructive sleep apnea. Sleep Breath. 2012 16:283–294
6. Zhang D, Hu X, Qian L, Wilson B, Flood P, Hong JS.  Microglial MAC1 receptor and PI3K are essential in mediating β-amyloid peptide-induced neurotoxicity in neuron/glia cultures. J Neuroinflammation. 2011 Jan 13;8(1):3.
7. Zhang D, Hu X, Hong JS. Astrogliosis in CNS pathologies: Is there a role for microglia? Molecular Neurobiology. 2010 Jun41(2-3):232-41.
8. Zhang D, Hu X, Qian L, Wilson B, Lee C, Flood P, Langenbach R, Hong JS. Prostaglandin E2 released from microglia enhances astrocyte proliferation. Toxicology and Applied Pharmacology 2009 Jul 1;238(1):64-70
9. Qian L, Hu X, Zhang D, Snyder A, Li Y, Wilson B, Hong JS, and Flood P. β2 adrenergic receptor activation induces microglial NADPH oxidase activation and dopaminergic neurotoxicity through an ERK- dependent/Protein Kinase A-independent pathway. Glia. 2009 Mar 27.
10. Hu X, Zhang D, Yang S, Wu H, Qian L, Chen P, Wei SJ, Wilson B, Hong JS. Macrophage antigen complex-1 mediates reactive microgliosis and progressive dopaminergic neurodegeneration in the MPTP model of Parkinson's disease. Journal of Immunology. 2008 Nov 15;181(10):7194-204.
11. Yang S, Zhang D, Yang Z, Hu X, Qian S, Liu J, Wilson B, Block M, Hong JS. Curcumin protects dopaminergic neuron against LPS induced neurotoxicity in primary rat neuron/glia culture. Neurochemical Research. 2008 Oct;33(10):2044-53.
12. Qian L, Wei S, Zhang D, Hu X, Xu Z, Wilson B, El-Benna J, Hong JS, Flood PM. Potent anti-inflammatory and neuroprotective effects of TGF-beta1 are mediated through the inhibition of ERK and p47phox-Ser345 phosphorylation and translocation in microglia. J Immunol. 2008 Jul 1;181(1):660-8
13. Zhang D, Hu X, Wei SJ, Liu J, Gao H, Qian L, Wilson B, Liu G, Hong JS. Squamosamide derivative FLZ protects dopaminergic neurons against inflammation-mediated neurodegeneration through the inhibition of NADPH oxidase activity. Journal of Neuroinflammation. 2008 May 28;5(1):21.
14. Zhang W, Dallas S, Zhang D, Guo JP, Pang H, Wilson B, Miller DS, Chen B, Zhang W, McGeer PL, Hong JS, Zhang J. Microglial PHOX and Mac-1 are essential to the enhanced dopaminergic neurodegeneration elicited by A30P and A53T mutant alpha-synuclein. Glia. 2007 Aug 15;55(11):1178-88
15. Zhang D, Zhang J, Liu G. The novel squamosamide derivative (compound FLZ) attenuated 1-methyl, 4-phenyl- pyridinium ion (MPP+)-induced apoptosis and alternations of related signal transduction in SH-SY5Y cells. Neuropharmacology. 2007,52(2): 423-429 
16. Zhang D, Zhang J, Liu G. The Novel squamosamide derivative FLZ protects against 6-hydroxydopamine-induced apoptosis through inhibition of related signal transduction in SH-SY5Y cells. European Journal of Pharmacology. 2007, 561(1-3):1-6
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