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王琰

时间:2020/7/17 来源: 阅读:36828次


王琰

王琰,女,博士,中国医学科学院药物研究所药物代谢室,研究员,博士生导师,研究室副主任。于2007年底回国,为药物所引进人才。目前,担任中国药学会药物分析专业委员会副主任委员,中国药理学会药物代谢专业委员会副主任委员,中国研究型医院学会过敏医学专业委员会常委,北京药物代谢专业委员会副主任委员,北京药学会应用与转化药学专业委员会副主任委员、北京药学会药物化学生物学专业委员会委员,《药学学报》、《中国药学杂志》、《药物分析杂志》、《中草药》编委等。

长期从事天然药物(天然活性成分)代谢转化、代谢动力学与药物分析等研究。近年来,致力于开展基于肠道菌的药物药理学研究,探索肠道菌作用下药物的代谢转化及分子机制,并建立了天然药物与肠道菌相互作用研究的技术平台,也开展多肽探针靶向早期结直肠癌诊断关键分子的鉴定及临床应用等。

 

联系方式

联系电话:0086-10-63165238(办公室)

电子邮箱:wangyan@imm.ac.cn

 

教育背景

2004/12- 2007/10,香港中文大学,中医药学院, 药学专业,博士

1997/09- 2000/06,北京协和医学院(原中国协和医科大学),药物分析专业,理学硕士

1988/08- 1992/07,上海第二军医大学,药学专业,理学学士

 

工作经历

2012/05-至今,中国医学科学院药物研究所药物代谢室,课题组长, 先后任副研究员,硕士生导师,研究员,博士生导师,研究室副主任;

2007/12-2012/04,中国医学科学院药物研究所分析室,课题组长,副研究员,硕士生导师;

2003/09-2004/12,先后两次赴美国康涅狄格老化与癌症研究所,访问学者;

2001/09-2003/06,中国医学科学院药物研究所新药开发二室,课题组长;

1995/10-2001/09,中国医学科学院药物研究所分析室,先后为实习研究员、助理研究员;

1992/09-1995/10,国防科工委(现总装备部)后勤部药检所,实习研究员。

 

专业研究方向领域

1 肠道菌作用下药物的代谢转化及分子基础;

2 我国原创的天然药物及天然活性成分的代谢转化及药代动力学的研究;

3 用于结直肠癌早期诊断的多肽探针体内代谢特征评价及关键技术研究;

4 基于手性拆分新技术和新方法,开展天然手性药物的药代研究。

 

承担的课题

迄今,牵头或负责了国家“863”计划、十二五十三五新药创制重大专项(子课题负责人)、中国医学科学院医学与健康科技创新工程-创新团队项目、国家自然科学基金面上项目、北京市自然基金重点项目、人事部、北京市科委等项目50 余项,主要参加了药物所创新药物-治疗老年痴呆新药左黄皮酰胺的研制。2002 年,获北京市科技新星培养计划资助。已发表论文近80篇,参加编写黄皮酰胺的化学和生物学活性(副主编)等。

 

近年发表论文

1.      Pan L, Han P, Ma S, Peng R, Wang C, Kong W, Cong L, Fu J, Zhang Z, Yu H, Wang Y*, Jiang J.D*. Abnormal metabolism of gut microbiota reveals the possible molecular mechanism of nephropathy induced by hyperuricemia. Acta Pharm Sin B. 2020 Feb; 10(2):249-261. doi: 10.1016/j.apsb. 2019.10.007. Epub 2019 Oct 30

2.      Peng R, Ma SR, Fu J, Han P, Pan LB, Zhang ZW, Yu H, Wang Y*. Transforming of Triptolide into Characteristic Metabolites by the Gut Microbiota. Molecules. 2020 Jan 30; 25(3). pii: E606. doi: 10.3390/molecules25030606.

3.      Wang C, Wang Y, Ma SR, Zuo ZY, Wu YB, Kong WJ*, Wang AP*, Jiang JD*.  Berberine inhibits adipocyte differentiation, proliferation and adiposity through down-regulating galectin-3. Sci Rep. 2019 Sep 16; 9(1):13415. doi: 10.1038/s41598-019-50103-5.

4.      Ma SR, Tong Q, Zhao ZX, Cong L, Yu JB, Fu J, Han P, Pan LB, Gu R, Peng R, Zhang ZW, Wang Y*, Jiang JD*. Determination of berberine-upregulated endogenous short-chain fatty acids through derivatization by 2-bromoacetophenone. Anal Bioanal Chem. 2019 Apr 10. doi: 10.1007/s00216-019-01793-3.

5.      Yu JB, Zhao ZX, Peng R, Pan LB, Fu J, Ma SR, Han P, Cong L, Zhang ZW, Sun LX, Jiang JD*, Wang Y*. Gut Microbiota-Based Pharmacokinetics and the Antidepressant Mechanism of Paeoniflorin. Front Pharmacol.  2019, 10: 268.

6.      Li C, Chen H, Lan Z, He S, Chen R, Wang F, Liu Z, Li K, Cheng L, Liu Y, Sun K, Wan X, Chen X, Peng H, Li L, Zhang Y, Jing Y, Huang M, Wang Y, Wang Y, Jiang J, Zha X, Chen L*, Zhang H*. mTOR-dependent upregulation of xCT blocks melanin synthesis and promotes tumorigenesis. Cell Death Differ. 2019 Feb 13. doi: 10.1038/s41418-019-0274-0.

7.      Zhen-Xiong Zhao, Jie Fu, Shu-Rong Ma, Ran Peng, Jin-Bo Yu, Lin Cong, Li-Bin Pan, Zuo-Guang Zhang, Hui Tian, Chun-Tao Che, Yan Wang*, Jian-Dong Jiang*. Gut-brain axis metabolic pathway regulates antidepressant efficacy of albiflorin. Theranostics. 2018 Nov 13; 8(21):5945-5959.

8.      王琰, 蒋建东*. 肠道菌介导的PK-PD 新模式: 小檗碱药代动力学引发的思考. 药学学报 Acta Pharmaceutica Sinica 2018, 53 (5): 659−666.

9.      Li CH, Tang SC, Wong CH, Wang Y*, Jiang JD*, Chen Y*. Berberine induces miR-373 expression in hepatocytes to inactivate hepatic steatosis associated AKT-S6 kinase pathway. Eur J Pharmacol. 2018 Apr 15; 825:107-118.

10.   Feng R, Zhao ZX, Ma SR, Guo F, Wang Y*, Jiang JD*. Gut microbiota-regulated pharmacokinetics of berberine and active metabolites in beagle dogs after oral administration. Front Pharmacol. 2018 Mar 21; 9:214.

11.   Yan Wang*, Qian Tong, Jia-Wen Shou, Zhen-Xiong Zhao, Xiao-Yang Li, Xian-Feng Zhang, Shu-Rong Ma, Chi-Yu He, Bao-Ying Wen, Fang Guo, Jie Fu, Jian-Dong Jiang*. Gut microbiota mediated personalized medicine in berberine treatment. Theranostics. 2017, 7(9):2443-2451.

12.   Chi-Yu He, Jie Fu, Jia-Wen Shou, Zhen-Xiong Zhao, Long Ren, Yan Wang* and Jian-Dong Jiang*. In vitro study of the metabolic characteristics of eight isoquinoline alkaloids from natural plants in rat gut microbiota. Molecules, 2017, 22: 932.

13.   Yan Wang*, Jia-Wen Shou, Xiao-Yang Li, Zhen-Xiong Zhao, Jie Fu, Chi-Yu He, Ru Feng, Chao Ma, Bao-Ying Wen, Fang Guo, Xin-Yi Yang, Yan-Xing Han, Lu-Lu Wang, Qian Tong, Xue-Fu You, Yuan Lin, Wei-Jia Kong, Shu-Yi Si, Jian-Dong Jiang*. Berberine-induced bioactive metabolites of gut microbiota improves energy metabolism. Metabolism, 2017, 70:72–84.

14.   潘利斌, 范辉政, 蒋建东, 王琰*. 微量元素硒的体内过程及生物学效应研究进展. 药学学报Acta Pharmaceutica Sinica 2017, 52 (12): 1849 −1858.

15.   Jian-Li Zhang, Yi-Nong Zhang, Yan Wang*. Validated quantification method for five ephedrines in dietary supplements using LC–MS/MS: Application to 503 cases. J Chromatogr B Analyt Technol Biomed Life Sci. 2016 Dec 15; 1039:1-7.doi: 10.1016/j.jchromb.2016.11.008. Epub 2016 Nov 9

16.   Jianli Zhang, Jianghai Lu*, Yun Wu, Xiao-Bing Wang, You-Xuan Xu, Yi-Nong Zhang, Yan Wang*. New potential biomarker for methasterone misuse in human urine by liquid chromatography quadruple time of flight mass spectrometry. Int J Mol Sci.

2016, 17: 4486-4492.

17.   Shi-Feng Chu, Shao-Lin Liu, Wen-Zhen Duan, Yong Cheng, Xue-Ying Jiang, Chuan-Jiang Zhu, Kang Tang, Run-Sheng Wang, Lin Xu, Xiao-YingWang, Xiao-Ming Yu, Ke-mei Wu, Yan Wang, Mu-ZouWang, Hui-Yong Huang, Jun-Tian Zhang. The anti-dementia drug candidate, (−)-clausenamide, improves memory impairment through its multi-target effect. Pharmacology & Therapeutics, 2016, 162: 179-187.

18.   Jing-Yi Ma, Xuelin Zhou, Jie Fu, Chi-Yu He, Ru Feng, Min Huang, Jia-Wen Shou, Zhen-Xiong Zhao, Xiao-Yang Li, Luye Zhang, Yang-Chao Chen, Yan Wang*. In vivo metabolite profiling of a purified ellagitannin isolated from Polygonum capitatum in Rats. Molecules, 2016, 21: 1110.

19.   Ru Feng, Xiang-Shan Tan, Bao-YingWen, Jia-Wen Shou, Jie Fu, Chi-Yu He, Zhen-Xiong Zhao, Xiao-Yang Li, Hui-Xin Zhu, Ping Zhu, Jian-Gong Shi, Chun-Tao Che, John H.K. Yeung, Xian-Feng Zhang*, Yan Wang*. Interaction effects on cytochrome P450 both in vitro and in vivo studies by two major bioactive xanthones from Halenia elliptica D. Don. Biomedical Chromatography, 2016, 30: 1953-1962.

20.   Chi-Yu He, Ru Feng, Yu-Peng Sun, Shi-Feng Chu, Ji Chen, Chao Ma, Jie Fu, Zhen-Xiong Zhao, Min Huang, Jia-Wen Shou, Xiao-Yang Li, Yu-Zhu Wang, Jin- Feng Hu, Yan Wang*, Jun-Tian Zhang*. Simultaneous quantification of ginsenoside Rg1 and its metabolites by high performance liquid chromatography–tandem mass spectrometry: Rg1 excretion in rat bile, urine, and feces. Acta Pharmaceutica Sinica B, 2016, 6:593-599.

21.   Bao-Hui Cheng, XuelinZhou, Yan Wang, Judy Yuet-Wa Chan, Huang-Quan Lin, Penelope M.Y. Or, David Chi-Cheong Wan, Ping-Chung Leung, Kwok-Pui Fung, Yi-Fen Wang, Clara Bik-San Lau. Herb–drug interaction between an anti-HIV Chinese herbal SH formula and a tazanavir in vitro and in vivo. J Ethnopharmacol, 2015 Mar 13; 162:369-76.

22.   Xiao‑Yang Li, Zhen‑Xiong Zhao, Min Huang, Ru Feng, Chi‑Yu He, Chao Ma, Shi‑Heng Luo, Jie Fu, Bao‑Ying Wen, Long Ren, Jia‑Wen Shou, Fang Guo, Yangchao Chen, Xin Gao, Yan Wang*, Jian‑Dong Jiang*. Effect of Berberine on promoting the excretion of cholesterol in high-fat diet-induced hyperlipidemic hamsters. Journal of Translational Medicine, 2015, 13(1): 278.

23.   Hong-Mei Yan , Ming-Feng Xia, Yan Wang, Xin-Xia Chang, Xiu-Zhong Yao, Sheng-Xiang Rao, Meng-Su Zeng, Yin-Fang Tu, Ru Feng, Wei-Ping Jia, Jun Liu, Wei Deng, Jian-Dong Jiang*, Xin Gao*. Efficacy of Berberine in Patients with Non-Alcoholic Fatty Liver Disease. PLoS One, 2015, 10 (8): e0134172.

24.   Ru Feng, Jia-Wen Shou, Zhen-Xiong Zhao, Chi-Yu He, Chao Ma, Min Huang, Jie Fu, Xiang-Shan Tan, Xiao-Yang Li, Bao-Ying Wen, Xi Chen, Xin-Yi Yang, Gang Ren, Yuan Lin, Yangchao Chen, Xue-Fu You, Yan Wang*, Jian-Dong Jiang*. Transforming berberine into its intestine absorbable form by gut microbiota. Scientific Reports, 2015, 5: 12155.

25.   Yan Wang*, Jia-Wen Shou, Jian-Dong Jiang*. Metabolism of Chinese Materia Medica in gut microbiota and biological effects. Chinese Herbal Medicines, 2015, 7(2): 109-115.

26.   Bao-Hui Cheng, Xuelin Zhou, Yan Wang, Judy Yuet-Wa Chan, Huang-Quan Lina, Penelope M.Y. Or, David Chi-Cheong Wan, Ping-Chung Leung, Kwok-Pui Funga, Yi-Fen Wang*, Clara Bik-San Laua*. Herb-drug interaction between an anti-HIV Chinese herbal SH formula and Atazanavir in vitro and in vivo. Journal of Ethnopharmacology, 2015, 162(13): 369-376.

27.   Zhangang Xiao, Chi Han Li, Stephen L. Chan, Feiyue Xu, Lu Feng, Yan Wang, Jian-Dong Jiang, Joseph JY Sung, Christopher HK Cheng, and Yangchao Chen*. A small-molecule modulator of the tumor-suppressor mir34a inhibits the growth of hepatocellular carcinoma. Cancer Research, 2014, 74(21): 6236-6247.

28.   Chi-Yu He, Jie Fu, Jing-Yi Ma, Ru Feng, Xiang-Shan Tan, Min Huang, Jia-Wen Shou, Zhen-Xiong Zhao, Xiao-Yang Li, Xian-Feng Zhang*, Yangchao Chen* and Yan Wang*. Biotransformation and in vitro metabolic profile of bioactive extracts from a traditional miao-nationality herbal medicine, Polygonum capitatum. Molecules, 2014, 19: 10291-10308.

29.   Jing-Yi Ma, Xuelin Zhou, Jie Fu, Tao Hu, Penelope M.Y. Or, Ru Feng, Chi-Yu He, Wen-Jing Chen, Xian-Feng Zhang*, Yangchao Chen**, Yan Wang***, John H.K. Yeung. Metabolite profiling analysis of FR429, an ellagitannin purified from Polygonum capitatum, in rat and human liver microsomes, cytosol and rat primary hepatocytes in vitro. Chemico-Biological Interactions, 2014, 220: 33-40.

30.   Ming Zhao*, Xianming Zhang, Yan Wang*, Min Huang, Jin-Ao Duan, Tanja Gödecke, Karina M. Szymulanska-Ramamurthy, Zhiqi Yin, Chun-Tao Che. Germacranes and m-Menthane from Illicium lanceolatum. Molecules, 2014, 19(4): 4326-4337.

31.   Ru Feng, Xuelin Zhou, Xiang-Shan Tan, Penelope M.Y. Or, Tao Hu, Jie Fu, Jing-Yi Ma, Min Huang, Chi-Yu He, Jian-Gong Shi, Chun-Tao Che, John H.K. Yeung*, Yan Wang*. In vitro identification of cytochrome P450 isoforms responsible for the metabolism of 1-hydroxyl-2, 3, 5-trimethoxy-xanthone purified from Halenia elliptica D. Don. Chemico-Biological Interactions, 2014, 210: 12-19.

32.   Yan Wang, Jing-Yi Ma, SC Chow, Chi-Han Li, Zhangang Xiao, Ru Feng, Jie Fu, Yangchao Chen*. A potential antitumor ellagitannin, davidiin, inhibited hepatocellular tumor growth by targeting EZH2. Tumor Biology, 2014, 35 (1): 205-212.

33.   Xiang-Shan Tan, Jing-Yi Ma, Ru Feng, Chao Ma, Wen-Jing Chen, Yu-Peng Sun, Jie Fu, Min Huang, Chi-Yu He, Jia-Wen Shou, Wen-Yi He, Yan Wang*, Jian-Dong Jiang*. Tissue distribution of Berberine and its metabolites after oral administration in rats. PLoS One, 2013, 8(10): e77969. doi:10.1371/journal.pone.0077969.

34.   Jing-Yi Ma, Ru Feng, Xiang-Shan Tan, Chao Ma, Jia-Wen Shou, Jie Fu, Min Huang, Chi-Yu He, Shuo-Nan Chen, Zhen-Xiong Zhao, Wen-Yi He, Yan Wang*, Jian-Dong Jiang**. Excretion of berberine and its metabolites in oral administration in rats. Journal of Pharmaceutical Sciences, 2013, 102(11): 4181-4192.

35.   Ming-Na Sun, Jin-Feng Hu, Xiu-Yun Song, Dong-Hui Wu, Ling-Lei Kong, Yu-Peng Sun, Dong-Mei Wang, Yan Wang**, Nai-Hong Chen***, Gang Liu*. Coumarin derivatives protect against ischemic brain injury in rats. European Journal of Medicinal Chemistry, 2013, 67: 39-53.

36.   Min Huang, Wen-Jing Chen, Ying Zhou, Ru Feng, Jie Fu, Jing-Yi Ma, Xiang-Shan Tan, Chi-Yu He ,Qi-Ming Zhang, Wen-Yi He, Yu-Lin Deng, Yu-Kui Zhang, Xian-Feng Zhang, Yan Wang*. Enantiomeric separations of four basic drugs containing N-alkyl groups by a RP-HPLC system using SBE-β-CD as chiral mobile phase additive. Chinese Chemical Letters, 2013, 24 (9): 840-844.

37.   赵朕雄,符洁,冯茹,王琰*,姚庆强*. GC-MS联用法分析不同产地白芍和赤芍的挥发油成分. 药物分析杂志, 2015, 35 (4): 627-634.

38.   谭湘姗, 冯茹,石建功,车镇涛,王琰*. 花锚𠮿酮化合物1-羟基-2, 3, 5-三甲氧基口山酮在大鼠肝脏微粒体中的代谢转化及CYP450酶亚型鉴定. 中国药学杂志, 2014, 49 (19): 1704-1709.

39.   阮飞盈, 陈日道, 李建华, 张敏, 解可波, 王琰, 冯茹, 戴均贵. 毛霉对柚皮素的硫酸酯化. 中国中药杂志, 2014, 39(11): 2039-2042.

 

近年专著

1.      《小檗碱》,2018年,科学出版社,参加第八章、十一章编写。

2.      The Chemistry and Biological Activities of (-)-Clasenamide, 2014年,化学工业出版社,副主编;

3.      《中草药现代研究》, 2010年,中国协和医科大学出版社, 参加莪术黄皮两章的编写;

4.      《常用中草药高效液相色谱分析》,1999, 科学出版社,参加部分编写。

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