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徐柏玲

时间:2021/6/18 来源: 阅读:29386次


徐柏玲

 

徐柏玲     学位:博士, 职称:研究员 博士生导师

 

联系方式

联系电话:010-63166764,邮箱: xubl@imm.ac.cn

 

 

教育背景

1992年毕业于东北师范大学化学系,获学士学位;1995年毕业于东北师范大学有机化学专业,获硕士学位;1998年毕业于中国医学科学院,中国协和医科大学药物研究所药物化学专业,获博士学位。

 

工作经历

19989月至200010月工作于药物研究所,任助理研究员。200011月到美国加洲大学戴维斯癌症研究中心做博士后,从事固相组合化学研究。20023月到弗吉尼亚理工大学做博士后,从事肽模拟物的设计与合成工作。20042月回到药物所工作,先后任助理研究员、副研究员和研究员。

 

专业研究方向领域

药物分子设计与合成

针对肿瘤、糖尿病和精神神经系统等疾病领域的生物大分子靶标,设计合成新结构的小分子化学实体,寻找干预疾病信号传导通路的先导结构,经结构修饰和优化,发现具有潜在治疗作用的侯选药物。

 

近年发表论文

1.    Lifei Du, Xiaoyu Wang, Guonan Cui, Bailing Xu* Design, synthesis and biological evaluation of novel thiazole-based derivatives as human Pin1 inhibitors, Bioorganic & Medicinal Chemistry, 2021, 29: 115878

2.    Jie Zhou#, Jianbo Bie#, Xiaoyu Wang#, Quan Liu, Rongcui Li, Hualong Chen, Jinping Hu, Hui Cao, Wenming Ji, Yan Li, Shuainan Liu*, Zhufang Shen*, Bailing Xu*Discovery of N-arylsulfonyl-indole-2-carboxamide Derivatives as Potent, Selective, and Orally Bioavailable Fructose-1,6-Bisphosphatase Inhibitors― Design, Synthesis, In Vivo Glucose Lowering Effects, and X-ray Crystal Complex Analysis, Journal of Medicinal Chemistry, 2020,10307-10329

3.    Cui Guonan#, Lai Fangfang#, Wang Xiaoyu, Chen Xiaoguang*, Xu Bailing* Design, synthesis and biological evaluation of indole-2-carboxylic acid derivatives as IDO1/TDO dual inhibitors, European Journal of Medicinal Chemistry, 2020,188: 111985

4.    Zhou jie#, Ji Ming#, Yao Haiping, Cao Ran, Zhao Hailong, Wang Xiaoyu, Chen Xiaoguang*, Xu Bailing* Discovery of quinazoline-2,4(1H,3H)-dione derivatives as novel PARP1/2 inhibitors: design,synthesis and their antitumor activity, Organic & Biomolecilar Chemistry, 2018, 16(17):3189-3202

5.    Cui Guonan#, Jin Jing#, Chen Hualong, Cao Ran, Chen Xiaoguang*, Xu Bailing* Synthesis and biological evaluation of pyrimidine derivatives as novel Pin1 inhibitors, Bioorganic & Medicinal Chemistry, 2018, 26(8): 2186-2197.

6.    Zhou jie#, Ji Ming#, Zhu Zhixiang, Cao Ran, Chen Xiaoguang*, Xu Bailing* Discovery of 2-substituted 1H-benzo[d]imidazole-4-carboxamide derivatives as novel poly(ADP-ribose)polymerase-1 inhibitors with in vivo anti-tumor activity, European Journal of Medicinal Chemistry, 2017,132: 26-41.

7.     Hailong Zhao#, Ming Ji#, Guonan Cui, Jie zhou, Fangfang Lai, Xiaoguang Chen*, Bailing Xu*  Discovery of novel quinazoline-2,4(1H,3H)-dione derivatives as potent PARP-2 selective inhibitors, Bioorgnic Medicinal Chemistry 2017, 25(15): 4045-4054.

8.    Hailong Zhao#, Guonan Cui#, Jing Jin, Xiaoguang Chen*, Bailing Xu*, Synthesis and Pin1 inhibitory activity of thiazole derivatives, Bioorgnic Medicinal Chemistry 2016, 24, 5911-5920.

9.    Haiping Yao#, Ming Ji# , Zhixiang Zhu, Jie zhou, Ran Cao, Xiaoguang Chen*, Bailing Xu*  Discovery of 1-substituted benzyl-quinazoline-2,4(1H,3H)-dione derivatives as novel poly(ADP-ribose)polymerase-1 inhibitors, Bioorgnic Medicinal Chemistry 2015, 23, 681-693.

10. Jianbo Bie#, Shuainan Liu# , Zhanmei Li, Yongzhao Mu, Bailing Xu* , Zhufang Shen*, Discovery of novel indole derivatives as allosteric inhibitors of fructose-1, 6-bisphosphatase, European Journal of Medicinal Chemistry, 2015, 90, 394-405.

11. Jianbo Bie, Shuainan Liu, Jie Zhou, Bailing Xu*, Zhufang Shen*, Design, synthesis and biological evaluation of 7-nitro-1H-indole-2-carboxylic acid derivatives as allosteric inhibitors of fructose-1,6-bisphosphatase, Bioorgnic Medicinal Chemistry 2014, 22, 1850-1862.

12. Jie Zhou,# Mingyu Ba#, Bo Wang, Haibo Zhou, Jianbo Bie, Decai Fu, Yingli Cao, Bailing Xu*, Ying Guo*, Synthesis and biological evaluation of novel quinoxalinone-based HIV-1 reverse transcriptase inhibitors, Med. Chem. Commun., 2014, 5, 441-444

13. Jie Zhou#, Jing Jin# , Yi Zhang, Yuwen, Yin, Xiaoguang Chen*, Bailing Xu*, Synthesis and antiproliferative evaluation of novel benzoimidazole-contained oxazole-bridged analogs of combretastatin A-4, European Journal of Medicinal Chemistry, 2013, 68, 222-232.

14. Chang Liu#, Jing Jin#, Liang Chen, Jie Zhou, Xiaoguang Chen*, Decai, Fu, Hongrui Song, Bailing Xu*. Synthesis and biological evaluation of novel human Pin1 inhibitors with benzophenone skeleton. Bioorg. Med. Chem. 2012, 20, 2992-2999.

 

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