副研究员，硕士生导师。2001年本科毕业于山东大学药学院，2004年获得山东省医学科学院药物研究所天然药物化学专业硕士学位，2008年获得中国医学科学院药物研究所药物化学专业博士学位。近年来，以质谱在生物医药中的应用研究为基础，结合化学生物学以及药物化学开展了抗肿瘤、抗糖尿病小分子抑制剂研究以及有机小分子探针生物成像应用研究。主持或参与科研项目共10项，其中主持国家自然青年基金项目1项，药物所基本科研业务费1项，参与的项目包括国家科技重大专项3项，国自然面上项目3项等。迄今在Analytical Chemistry，Acta Pharmaceutica Sinica B，Chemical Communications，Journal of Medicinal Chemistry 等期刊发表论文10余篇。

1.质谱分析应用研究；
2.有机小分子探针生物成像应用研究

1. A single component self-assembled thermally activated delayed fluorescence nanoprobe, Rao Wei†, Leilei Zhang†, Shengnan Xu, Qingyang Zhang, Yongxiu Qi*, Hai-Yu Hu*, Chemical Communications, 2020，56(17): 2550-2553.
2. Gadolinium-Labeled Aminoglycoside and Its Potential Application as a Bacteria-Targeting Magnetic Resonance Imaging Contrast Agent, Leilei Zhang†, Yun Liu†, Qingyang Zhang, Tiegang Li, Min Yang, Qingqiang Yao, Xilei Xie, Hai-Yu Hu*, Analytical Chemistry, 2018，90(3): 1934-1940.
3. A novel nitroreductase-enhanced MRI contrast agent and its potential application in bacterial imaging, Yun Liu, Leilei Zhang*, Marc Nazare, Qingqiang Yao*, Hai-Yu Hu*, Acta Pharmaceutica Sinica B, 2018，8(3): 401-408.
4. Identification of peptide substrate and small molecule inhibitors of testis-specific serine/threonine kinase1 (TSSK1) by the developed assays, Leilei Zhang, Yan Yu, Zijie Liu, Zeper Abliz, Gang Liu*, Journal of Medicinal Chemistry, 2009, 52, 4419-4428.
5. Identification of 3, 5, 6-substituted indolin-2-one’s inhibitors of aurora B by development of a luminescent kinase assay, Leilei Zhang, Tianming Yang, Xilei Xie, Gang Liu*, Bioorganic & Medicinal Chemistry Letters, 2015, 25, 2937-2942.
6. Simultaneous quantification of six major triterpenoid saponins in Schefflera kwangsiensis using high-performance liquid chromatography coupled to orbitrap mass spectrometry. Leilei Zhang*†, Yan Wang†, Dequan Yu*, Natural product research, 2015，29, 1350-1357.
7. Design, Synthesis and Evaluation of Novel Derivatives of Orotic Acid Amide as Potent Glucokinase Activators, Leilei Zhang, Shengquan Hu, Lei Lei, Yuliang Zhang, Lijing Zhang, Hongrui Song, Zhufang Shen, Zhiqiang Feng*, Letters in Drug Design & Discovery, 2017， 14, 252- 261.
8. The stereoselective C-alkylation of chiral nitronic acid (4S*, 5R) -(+)-4-(6-nitro-6-carbethoxymethyl)-5-[(1R)-menthyloxy]-3,4-dihydro-2(5H)-furanone, Leilei Zhang, Zhiqiang Feng*, J. Indian Chem. Soc., 2014，91, 1335-1339.
9. (±)-F18对映异构体的HPLC手性分离、绝对构型确定以及抗HIV-1活性研究，张蕾磊，薛海，李莉，陆小凡，陈志伟，刘刚*，药学学报，2015.

1、 超敏感荧光探针检验细菌中硝基还原酶及在细菌感染应用，CN201911008897.1.
2、 一种热激活延迟荧光探针分子、其制备及其在细胞成像中的应用, CN201910163693.9.